Caffeine eliminates psychomotor vigilance deficits from sleep inertia
Van Dongen HP, Price NJ, Mullington JM, Szuba MP, Kapoor SC, Dinges DF
Sleep · 136 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (RR 00040)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2001-10-01 · Sleep · vol. 24 · número 7 · págs. 813–819
- Editorial
- Oxford University Press
- Citado
- 219 citas · más que el 98% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- caffeine, sleep inertia, psychomotor vigilance, adenosine receptors, adenosine, wakefulness, NAP, extended wakefulness
- MeSH
- humans, psychomotor disorders, caffeine, central nervous system stimulants, polysomnography, double-blind method, arousal, wakefulness, reaction time, sleep, rem, circadian rhythm, adult, middle aged, sleep wake disorders
6 autores
- Hans P. A. Van Dongen🇺🇸 · autor de correspondenciaUniversity of Pennsylvania
- Nicholas J. Price🇺🇸University of Pennsylvania
- Janet M. Mullington🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Martin P. Szuba🇺🇸University of Pennsylvania
- Shiv C. Kapoor🇺🇸Hospital of the University of Pennsylvania
- David F. Dinges🇺🇸University of Pennsylvania
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study objectives
This study sought to establish the effects of caffeine on sleep inertia, which is the ubiquitous phenomenon of cognitive performance impairment, grogginess and tendency to return to sleep immediately after awakening.
Design
28 normal adult volunteers were administered sustained low-dose caffeine or placebo (randomized double-blind) during the last 66 hours of an 88-hour period of extended wakefulness that included seven 2-hour naps during which polysomnographical recordings were made. Every 2 hours of wakefulness, and immediately after abrupt awakening from the naps, psychomotor vigilance performance was tested.
Setting
N/A.
Participants
N/A.
Interventions
N/A.
Measurements and results
In the placebo condition, sleep inertia was manifested as significantly impaired psychomotor vigilance upon awakening from the naps. This impairment was absent in the caffeine condition. Caffeine had only modest effects on nap sleep.
Conclusions
Caffeine was efficacious in overcoming sleep inertia. This suggests a reason for the popularity of caffeine-containing beverages after awakening. Caffeine's main mechanism of action on the central nervous system is antagonism of adenosine receptors. Thus, increased adenosine in the brain upon awakening may be the cause of sleep inertia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.