Calcium and vitamin D supplements reduce tooth loss in the elderly
Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B
The American journal of medicine · 173 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Dental and Craniofacial Research
- Gobierno
- NIA NIH HHS
- Gobierno
- NIDCR NIH HHS
- Subvenciones
- National Institute on Aging (AG-10353); National Institute of Dental and Craniofacial Research (K24 DE 00419)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2001-10-01 · Am J Med · vol. 111 · número 6 · págs. 452–456
- Editorial
- Elsevier BV
- Citado
- 312 citas · más que el 99% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dental Health and Care Utilization · Vitamin D Research Studies · Bone health and osteoporosis research
- Palabras clave
- calcium supplementation, vitamin D supplementation, tooth loss, tooth preservation, older adults, osteoporosis prevention, hip bone loss, periodontal disease, dental caries, oral hygiene
- MeSH
- femur neck, tooth, humans, osteoporosis, tooth loss, calcium, dietary, calcium, malates, citric acid, cholecalciferol, radiography, oral hygiene, odds ratio, follow-up studies, double-blind method, bone density, dietary supplements, aged, oral health, female, male
5 autores
- Elizabeth A. Krall🇺🇸 · autor de correspondenciaBoston University; Tufts University; United States Department of Agriculture; Jean Mayer Human Nutrition Research Center on Aging
- Carolyn J. Wehler🇺🇸Boston University
- Raul I. García🇺🇸Boston University; VA Boston Healthcare System
- Susan S. Harris🇺🇸Tufts University; United States Department of Agriculture; Jean Mayer Human Nutrition Research Center on Aging
- Bess Dawson‐Hughes🇺🇸Tufts University; United States Department of Agriculture; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Oral bone and tooth loss are correlated with bone loss at nonoral sites. Calcium and vitamin D supplementation slow the rate of bone loss from various skeletal sites, but it is not known if intake of these nutrients affects oral bone and, in turn, tooth retention.
Subjects and methods
Tooth loss was examined in 145 healthy subjects aged 65 years and older who completed a 3-year, randomized, placebo-controlled trial of the effect of calcium and vitamin D supplementation on bone loss from the hip, as well as a 2-year follow-up study after discontinuation of study supplements. Teeth were counted at 18 months and 5 years. A comprehensive oral examination at 5 years included assessment of caries, oral hygiene, and periodontal disease. The odds ratio (OR) and 95% confidence interval (CI) of tooth loss were estimated by stepwise multivariate logistic regression. Initial age (mean +/- SD) of subjects was 71 +/- 5 years, and the number of teeth remaining was 22 +/- 7.
Results
During the randomized trial, 11 of the 82 subjects (13%) taking supplements and 17 of the 63 subjects (27%) taking placebo lost one or more teeth (OR = 0.4; 95% CI: 0.2 to 0.9). During the 2-year follow-up period, 31 of the 77 subjects (40%) with total calcium intake of at least 1000 mg per day lost one or more teeth compared with 40 of the 68 subjects (59%) who consumed less (OR = 0.5; 95% CI: 0.2 to 0.9).
Conclusion
These findings suggest that intake levels of calcium and vitamin D aimed at preventing osteoporosis have a beneficial effect on tooth retention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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