Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial
Jang Y, Lee JH, Kim OY, Park HY, Lee SY
Arteriosclerosis, thrombosis, and vascular biology · 119 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2001-12-01 · Arterioscler Thromb Vasc Biol · vol. 21 · número 12 · págs. 2065–2071
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 187 citas · más que el 98% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- whole grains, coronary artery disease, insulin requirement, lipid peroxidation, homocysteine, malondialdehyde, 8-isoprostane, oral glucose tolerance test, plasma glucose, dietary fiber, vitamin E, carotenoids, omega-6 fatty acids, serum phospholipids, diabetes mellitus
- MeSH
- humans, fabaceae, coronary disease, diabetes mellitus, diabetes complications, malondialdehyde, carotenoids, insulin, blood glucose, f2-isoprostanes, dinoprost, homocysteine, powders, glucose tolerance test, area under curve, risk factors, lipid peroxidation, middle aged, male, cholesterol, hdl, edible grain
5 autores
- Yangsoo Jang🇰🇷Yonsei University; Yonsei University Health System
- Jong Ho Lee🇰🇷Yonsei University; Yonsei University Health System
- Oh Yoen Kim🇰🇷Yonsei University; Yonsei University Health System
- Hyun Young Park🇰🇷Yonsei University; Yonsei University Health System
- Sang Yun Lee🇰🇷Yonsei University; Yonsei University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Our objective was to evaluate whether isocaloric replacement of refined rice with whole grains and other plant products as a form of powder reduces coronary artery disease (CAD) risk factors, such as insulin demand and lipid peroxidation in CAD patients. Seventy-six male patients with CAD were randomly assigned to either a group ingesting a whole-grain meal daily or a control group for 16 weeks. In the whole-grain group, serum concentrations of glucose and insulin decreased by 24% and 14%, respectively, without altering body weight and energy intake, whereas daily intakes of fiber and vitamin E increased by 25% and 41%, respectively. Consumption of whole grains and legume powder in CAD patients without diabetes decreased fasting levels of glucose and insulin. The areas under the curve for insulin and glucose during the oral glucose tolerance test were also decreased. CAD patients with diabetes in the whole-grain group also showed reductions in fasting glucose and in the area under the curve for glucose. In the whole-grain group, plasma malondialdehyde and homocysteine and urinary 8-epi-prostaglandin F(2alpha) concentrations decreased by approximately 28%. Also, lipid-corrected concentrations of alpha-carotene, retinol, tocopherols, and lycopene increased by 11% to 40%, and the percentage composition of n-6 fatty acids of serum phospholipid increased by 14% in the whole-grain group. The replacement of refined rice with whole grain and legume powder as a source of carbohydrate in a meal showed significant beneficial effects on glucose, insulin, and homocysteine concentrations and lipid peroxidation in CAD patients. These effects are likely to substantially reduce the risk factors for CAD and diabetes.
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