Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury
Jacobs PL, Mahoney ET, Cohn KA, Sheradsky LF, Green BA
Archives of physical medicine and rehabilitation · 38 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-01-01 · Arch Phys Med Rehabil · vol. 83 · número 1 · págs. 19–23
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 70% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Spinal Cord Injury Research · Cardiovascular and exercise physiology
- Palabras clave
- creatine monohydrate, oral supplementation, cervical spinal cord injury, arm ergometry, peak power, exercise capacity, oxygen consumption, fatigue, complete spinal cord injury
- MeSH
- arm, cervical vertebrae, humans, spinal cord injuries, creatine, administration, oral, analysis of variance, cross-over studies, double-blind method, exercise tolerance, adult, middle aged
5 autores
- Patrick L. Jacobs🇺🇸University of Miami
- Edward T. Mahoney🇺🇸University of Miami
- Kelly A. Cohn🇺🇸University of Miami
- Laurey F. Sheradsky🇺🇸University of Miami
- Barth A. Green🇺🇸University of Miami
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI).
Design
Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period.
Setting
University research laboratory trial.
Participants
Sixteen men with complete cervical-level SCI (C5-7).
Intervention
Subjects were randomly assigned to 1 of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion.
Main outcome measures
Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (VO2), minute ventilation, tidal volume (VT), and respiration frequency.
Results
Significantly greater values of VO2, VCO2, and VT at peak effort after creatine supplementation (P <.001).
Conclusions
Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits.
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