Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine
Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ
Psychopharmacology · 135 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Defense
- Gobierno
- U.S. Army Materiel Command
- Gobierno
- U.S. Army Medical Command
- Gobierno
- Medical Research and Materiel Command
Según 4 financiadores declarados.
Publicación
- Publicado
- 2001-10-19 · Psychopharmacology (Berl) · vol. 159 · número 3 · págs. 238–247
- Editorial
- Springer Science+Business Media
- Citado
- 404 citas · más que el 99% de estudios similares · 15.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Sleep and Wakefulness Research
- Palabras clave
- modafinil, caffeine, sleep deprivation, alertness, cognitive performance, circadian rhythm, dose-response relationship, stimulants, healthy young adults
- MeSH
- humans, sleep deprivation, benzhydryl compounds, caffeine, central nervous system stimulants, body temperature, administration, oral, analysis of variance, double-blind method, cognition, psychomotor performance, wakefulness, reaction time, sleep stages, circadian rhythm, dose-response relationship, drug, adolescent, adult, female, male, modafinil
6 autores
- Nancy Jo Wesensten🇺🇸Walter Reed Army Institute of Research
- Gregory Lucas Belenky🇺🇸Walter Reed Army Institute of Research
- Mary A. Kautz🇺🇸Walter Reed Army Institute of Research
- David R. Thorne🇺🇸Walter Reed Army Institute of Research
- Rebecca M. Reichardt🇺🇸Walter Reed Army Institute of Research
- Thomas J. Balkin🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
The performance and alertness effects of modafinil were evaluated to determine whether modafinil should replace caffeine for restoring performance and alertness during total sleep deprivation in otherwise healthy adults.
Objectives
Study objectives were to determine (a) the relative efficacy of three doses of modafinil versus an active control dose of caffeine 600 mg; (b) whether modafinil effects are dose-dependent; and (c) the extent to which both agents maintain performance and alertness during the circadian trough.
Methods
Fifty healthy young adults remained awake for 54.5 h (from 6:30 a.m. day 1 to 1:00 p.m. on day 3) and performance and alertness tests were administered bi-hourly from 8:00 a.m. day 1 until 10:00 p.m. day 2. At 11:55 p.m. on day 2 (after 41.5 h awake), subjects received double blind administration of one of five drug doses: placebo; modafinil 100, 200, or 400 mg; or caffeine 600 mg ( n=10 per group), followed by hourly testing from midnight through 12:00 p.m. on day 3.
Results
Performance and alertness were significantly improved by modafinil 200 and 400 mg relative to placebo, and effects were comparable to those obtained with caffeine 600 mg. Although a trend toward better performance at higher modafinil doses suggested a dose-dependent effect, differences between modafinil doses were not significant. Performance enhancing effects were especially salient during the circadian nadir (6:00 a.m. through 10:00 a.m.). Few instances of adverse subjective side effects (nausea, heart pounding) were reported.
Conclusions
Like caffeine, modafinil maintained performance and alertness during the early morning hours, when the combined effects of sleep loss and the circadian trough of performance and alertness trough were manifest. Thus, equivalent performance- and alertness-enhancing effects were obtained with drugs possessing different mechanisms of action. However, modafinil does not appear to offer advantages over caffeine (which is more readily available and less expensive) for improving performance and alertness during sleep loss in otherwise normal, healthy adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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