Financiado en parte por Nestec
Slow release caffeine and prolonged (64-h) continuous wakefulness: effects on vigilance and cognitive performance
Beaumont M, Batejat D, Pierard C, Coste O, Doireau P, Van Beers P, Chauffard F, Chassard D, Enslen M, Denis JB, Lagarde D
Journal of sleep research · 60 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nestec
Según 1 financiador declarado.
Publicación
- Publicado
- 2001-12-13 · J Sleep Res · vol. 10 · número 4 · págs. 265–276
- Editorial
- Wiley
- Citado
- 116 citas · más que el 97% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Sleep and Wakefulness Research
- Palabras clave
- sleep deprivation, prolonged wakefulness, sustained attention, cognitive performance, alertness, divided attention, working memory, Stroop task, multiple sleep latency test, shift work
- MeSH
- humans, sleep deprivation, caffeine, central nervous system stimulants, delayed-action preparations, body temperature, cross-over studies, double-blind method, cognition, arousal, wakefulness, time factors, adult, male
11 autores
- Maurice Beaumont🇫🇷 · autor de correspondenciaService de Santé des Armées
- Denise Batéjat🇫🇷Service de Santé des Armées
- Christophe Piérard🇫🇷Service de Santé des Armées
- Olivier Coste🇫🇷Service de Santé des Armées
- P. Doireau🇫🇷Hôpital d'instruction des Armées Percy
- Pascal Van Beers🇫🇷Service de Santé des Armées
- Françoise Chauffard🇨🇭Nestec (Switzerland)
- Didier Chassard
- Marc Enslen🇨🇭Nestec (Switzerland)
- J. B. Denis🇫🇷Hôpital d'instruction des Armées Percy
- Didier Lagarde🇫🇷Direction Générale de l'Armement
Resumen
El texto original del estudio, en el idioma en que se publicó.
Some long work or shift work schedules necessitate an elevated and prolonged level of vigilance and performance but often result in sleep deprivation (SD), fatigue and sleepiness, which may impair efficiency. This study investigated the effects of a slow-release caffeine [(SRC) at the daily dose of 600 mg] on vigilance and cognitive performance during a 64 h continuous wakefulness period. Sixteen healthy males volunteered for this double-blind, randomised, placebo controlled, two-way crossover study. A total of 300-mg SRC or placebo (PBO) was given twice a day at 21:00 and 9:00 h during the SD period. Vigilance was objectively assessed with continuous electroencephalogram (EEG), the multiple sleep latency tests (MSLT) and wrist actigraphy. Cognitive functions (information processing and working memory), selective and divided attention were determined with computerised tests from the AGARD-NATO STRES Battery (Standardised Tests for Research with Environmental Stressors). Attention was also assessed with a symbol cancellation task and a Stroop's test; alertness was appreciated from visual analogue scales (VAS). Tests were performed at the hypo (02:00-04:00 h, 14:00-16:00 h) and hypervigilance (10:00-12:00 h, 22:00-00:00 h) periods during SD. Central temperature was continuously measured and safety of treatment was assessed from repeated clinical examinations. Compared with PBO, MSLT showed that SRC subjects were more vigilant from the onset (P=0.001) to the end of SD (P < 0.0001) whereas some cognitive functions were improved till the thirty third of SD but others were ameliorated through all the SD period and alertness was better from the thirteenth hour of SD, as shown by Stroop's test (P=0.048). We showed that 300-mg SRC given twice daily during a 64-h SD is able to antagonize the impairment produced on vigilance and cognitive functions.
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