Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial
Meyer HE, Smedshaug GB, Kvaavik E, Falch JA, Tverdal A, Pedersen JI
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 149 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-04-01 · J Bone Miner Res · vol. 17 · número 4 · págs. 709–715
- Editorial
- Oxford University Press
- Citado
- 226 citas · más que el 98% de estudios similares · 8.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, vitamin D3, hip fracture, fragility fractures, osteoporotic fractures, non-vertebral fractures, nursing home residents, older adults, cod liver oil, 25-hydroxyvitamin D, fracture prevention, frail elderly
- MeSH
- humans, osteoporosis, cod liver oil, vitamin d, incidence, risk factors, dietary supplements, aged, aged, 80 and over, female, male, fractures, bone
6 autores
- Helmut E. Meyer🇳🇴 · autor de correspondenciaUniversity of Oslo
- Guro Berge Smedshaug🇳🇴University of Oslo
- Elisabeth Kvaavik🇳🇴University of Oslo
- Jan Arvid Falch
- Aage Tverdal
- Jan Ivar Pedersen🇳🇴University of Oslo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Randomized controlled trials have shown that a combination of vitamin D and calcium can prevent fragility fractures in the elderly. Whether this effect is attributed to the combination of vitamin D and calcium or to one of these nutrients alone is not known. We studied if an intervention with 10 microg of vitamin D3 per day could prevent hip fracture and other osteoporotic fractures in a double-blinded randomized controlled trial. Residents from 51 nursing homes were allocated randomly to receive 5 ml of ordinary cod liver oil (n = 569) or 5 ml of cod liver oil where vitamin D was removed (n = 575). During the study period of 2 years, fractures and deaths were registered, and the principal analysis was performed on the intention-to-treat basis. Biochemical markers were measured at baseline and after 1 year in a subsample. Forty-seven persons in the control group and 50 persons in the vitamin D group suffered a hip fracture. The corresponding figures for all nonvertebral fractures were 76 persons (control group) and 69 persons (vitamin D group). There was no difference in the incidence of hip fracture (p = 0.66, log-rank test), or in the incidence of all nonvertebral fractures (p = 0.60, log-rank test) in the vitamin D group compared with the control group. Compared with the control group, persons in the vitamin D group increased their serum 25-hydroxyvitamin D concentration with 22 nmol/liter (p = 0.001). In conclusion, we found that an intervention with 10 microg of vitamin D3 alone produced no fracture-preventing effect in a nursing home population of frail elderly people.
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