Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
Pins JJ, Geleva D, Keenan JM, Frazel C, O'Connor PJ, Cherney LM
The Journal of family practice · 71 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-04-01 · J Fam Pract · vol. 51 · número 4 · págs. 353–9
- Editorial
- National Institutes of Health
- Citado
- 136 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Blood Pressure and Hypertension Studies · Food composition and properties · Sodium Intake and Health
- Palabras clave
- whole grain oats, hypertension, antihypertensive medication reduction, blood pressure control, soluble dietary fiber, LDL cholesterol, total cholesterol, plasma glucose, fasting insulin, cardiovascular risk
- MeSH
- humans, hypertension, cholesterol, blood glucose, triglycerides, antihypertensive agents, regression analysis, dietary fiber, adult, aged, middle aged, female, male, avena
6 autores
- Joel J. Pins🇺🇸University of Minnesota
- Daniela Geleva
- Joseph Michael Keenan
- Christina Frazel
- Patrick J. O’Connor
- Linda M. Cherney
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Our study compared 2 whole grain oat-based cereals with 2 refined grain wheat-based cereals to determine their effects on the need for antihypertensive medications in people with high blood pressure (BP).
Study design
This 12-week, randomized controlled parallel-group trial with = 6 weeks of voluntary follow-up was designed to investigate the antihypertensive effects of oats. After 4 weeks of baseline feeding, medication dose was maintained or reduced by half or completely throughout the middle 4 weeks of the study. In the final 4 weeks, participants continued cereal consumption; medication was adjusted according to the protocol.
Population
Men and women (n = 88) being treated for hypertension with a mean baseline BP below 160/100.
Outcomes measured
Primary study outcomes included change in SBP and DBP as well as antihypertensive medication reduction. Secondary measures included blood lipid, fasting glucose, and insulin levels and side effects related to elevated BP and increased dietary fiber intake.
Results
Seventy-three percent of participants in the oats group versus 42% in the control group were able to stop or reduce their medication by half. Treatment group participants whose medication was not reduced had substantial decreases in BP. The oats group experienced a 24.2-mg/dL reduction in total cholesterol levels, a 16.2-mg/dL decrease in low-density lipoprotein cholesterol levels, and a 15.03-mg/dL drop in plasma glucose levels vs controls.
Conclusions
Results suggest that a diet containing soluble fiber-rich whole oats can significantly reduce the need for antihypertensive medication and improve BP control. Considering the lipid and glucose improvements as well, increased consumption of whole oats may significantly reduce cardiovascular disease risk.
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