Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men
Schurgers LJ, Shearer MJ, Soute BA, Elmadfa I, Harvey J, Wagner KH, Tomasch R, Vermeer C
Journal of lipid research · 8 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-06-01 · J Lipid Res · vol. 43 · número 6 · págs. 878–884
- Editorial
- Elsevier BV
- Citado
- 13 citas · más que el 71% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin K Research Studies · Antioxidant Activity and Oxidative Stress · Fatty Acid Research and Health
- Palabras clave
- vitamin K metabolism, vitamin K1, corn oil, olive oil, sunflower oil, gamma-carboxylation, osteocalcin, matrix Gla protein, vitamin E, polyunsaturated fatty acids, triglycerides, vitamin K-dependent proteins, dietary fat
- MeSH
- humans, vitamin k, corn oil, triglycerides, plant oils, adult, male, olive oil, sunflower oil
8 autores
- Leon J. Schurgers🇳🇱Maastricht University
- Martin J. Shearer🇬🇧St Thomas' Hospital
- Berry A.M. Soute🇳🇱Maastricht University
- Ibrahim Elmadfa🇦🇹University of Vienna
- Julia Harvey🇬🇧St Thomas' Hospital
- Karl‐Heinz Wagner🇦🇹University of Vienna
- R. Tomasch🇦🇹University of Vienna
- Cees Vermeer🇳🇱 · autor de correspondenciaMaastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Little is known of how the fat components of diets influence the absorption and metabolism of vitamin K and the possible consequences to the synthesis of vitamin K-dependent (VKD) proteins in different target organs. We have evaluated the effects of two diets on circulating phylloquinone (K1) and triacylglycerols (TAG). One diet was enriched with corn oil (CO) (also rich in gamma-tocopherol) and the other with an olive/sunflower (O/SO) mixture (rich in alpha-tocopherol). Effects on gamma-carboxylation were assessed from coagulation assays and sensitive assays for undercarboxylated prothrombin (ucFII) and osteocalcin (ucOC). Total plasma matrix Gla-protein (MGP) was also measured. After an initial adjustment diet, 26 healthy young men were fed, in a crossover design, the O/SO or CO diet for 2 weeks. Mean intakes of K1 during consumption of adjustment, O/SO, and CO diets were 225 microg/day, 291 microg/day, and 291 microg/day, respectively. Mean fasting levels of TAG and K1 were both significantly reduced by the CO diet, but not by the O/SO diet. Neither diet reduced FII activity but ucFII became detectable in nine subjects, eight of whom showed this abnormality with both diets. The CO diet induced a rise in ucOC (P < 0.05), which was negatively correlated to ucFII (r = -0.71, P < 0.03). The CO but not O/SO diet induced a decrease of total circulating MGP. We conclude that both oils, notably CO, affected vitamin K absorption and/or metabolism which may increase the requirements for gamma-carboxylation. The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E.
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