Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula
Innis SM, Adamkin DH, Hall RT, Kalhan SC, Lair C, Lim M, Stevens DC, Twist PF, Diersen-Schade DA, Harris CL, Merkel KL, Hansen JW
The Journal of pediatrics · 97 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-05-01 · J Pediatr · vol. 140 · número 5 · págs. 547–554
- Editorial
- Elsevier BV
- Citado
- 149 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Neonatal skin health care
- Palabras clave
- docosahexaenoic acid, arachidonic acid, preterm infants, preterm formula, infant growth, weight gain, visual acuity, phosphatidylethanolamine, fatty acid supplementation
- MeSH
- humans, docosahexaenoic acids, arachidonic acid, anthropometry, analysis of variance, prospective studies, double-blind method, growth, visual acuity, infant food, infant, newborn, infant, premature
12 autores
- Sheila Margaret Innis🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- David H. Adamkin🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Robert T. Hall🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Satish C. Kalhan🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Cheryl S. Lair🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Mary O. Lim🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Dennis C. Stevens🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Paul F. Twist🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Deborah A. Diersen-Schade🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Cheryl L. Harris🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- Kimberly L. Merkel🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
- James W. Hansen🇺🇸🇨🇦Winthrop-University Hospital; University of British Columbia; University of Louisville; University of South Dakota; Mead Johnson (United States); Pomona Valley Hospital Medical Center; Rainbow Babies & Children's Hospital; The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine if docosahexaenoic acid (DHA) and arachidonic acid (ARA) supplementation influences growth or visual acuity of formula-fed premature infants.
Study design
Double-blind, multi-center study of 194 premature infants given preterm formula with no DHA or ARA (control), 0.15% energy DHA, or 0.14% DHA + 0.27% ARA from single-cell triglycerides for at least 28 days and then fed term formula (no DHA or ARA) to 57 weeks postmenstrual age (PMA), with 90 breast-fed term infants as reference.
Results
Infants fed DHA+ARA formula gained weight significantly faster (post-hoc analysis) during preterm formula feeding than control infants (34.7 vs. 30.7 g/d) and had weights and weight:length ratios not different from term breast-fed infants at 48 and 57 weeks PMA. Infants fed control or DHA formula had lower body weights than term infants. Red blood cell phosphatidylethanolamine ARA was significantly correlated to weight gain during preterm formula feeding and to weight and length at 40, 48, and 57 weeks PMA (r = 0.19 to 0.24, P =.004-.02). Providing DHA or DHA+ARA during the preterm period had no effect on subsequent visual acuity or incidence of adverse events.
Conclusions
Feeding DHA+ARA from single-cell triglycerides enhances weight gain in formula-fed premature infants with no evidence of adverse effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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