Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial
Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA, Strauss R, Meredith T
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 107 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-26687)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2002-05-01 · Int J Obes Relat Metab Disord · vol. 26 · número 5 · págs. 593–604
- Editorial
- Springer Nature
- Citado
- 202 citas · más que el 99% de estudios similares · 11.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pharmacology and Obesity Treatment · Coffee research and impacts · Medicinal Plants and Bioactive Compounds
- Palabras clave
- Ephedra, caffeine, Ma Huang, kola nut, herbal weight loss supplements, obesity, weight loss, fat mass, serum lipids, LDL cholesterol, HDL cholesterol, blood pressure, heart rate, cardiac arrhythmias, adverse events, xerostomia, heartburn, insomnia, long-term safety
- MeSH
- humans, cola, ephedra, ephedra sinica, body weight, weight loss, ephedrine, caffeine, cholesterol, blood glucose, triglycerides, plant preparations, placebos, electrocardiography, ambulatory, prospective studies, patient compliance, body composition, blood pressure, heart rate, dietary supplements, cholesterol, ldl, cholesterol, hdl
8 autores
- CN Boozer🇺🇸 · autor de correspondenciaSt. Luke's-Roosevelt Hospital Center; Columbia University
- PA Daly🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Peter Homel🇺🇸Mount Sinai Beth Israel
- JL Solomon🇺🇸St. Luke's-Roosevelt Hospital Center; Columbia University
- D Blanchard🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- JA Nasser🇺🇸St. Luke's-Roosevelt Hospital Center; Columbia University
- Ross Strauss🇺🇸Cigna (United States)
- T. J. Meredith🇨🇭🇺🇸World Health Organization; Vanderbilt University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine long-term safety and efficacy for weight loss of an herbal Ma Huang and Kola nut supplement (90/192 mg/day ephedrine alkaloids/caffeine).
Design
Six-month randomized, double-blind placebo controlled trial.
Subjects
A total of 167 subjects (body mass index (BMI) 31.8+/-4.1 kg/m(2)) randomized to placebo (n=84) or herbal treatment (n=83) at two outpatient weight control research units.
Measurements
Primary outcome measurements were changes in blood pressure, heart function and body weight. Secondary variables included body composition and metabolic changes.
Results
By last observation carried forward analysis, herbal vs placebo treatment decreased body weight (-5.3+/-5.0 vs. -2.6+/-3.2 kg, P0.05). By self-report, dry mouth (P<0.01), heartburn (P<0.05), and insomnia (P<0.01) were increased and diarrhea decreased (P<0.05). Irritability, nausea, chest pain and palpitations did not differ, nor did numbers of subjects who withdrew.
Conclusions
In this 6-month placebo-controlled trial, herbal ephedra/caffeine (90/192 mg/day) promoted body weight and body fat reduction and improved blood lipids without significant adverse events.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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