Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge
Herron KL, Vega-Lopez S, Conde K, Ramjiganesh T, Roy S, Shachter NS, Fernandez ML
Journal of the American College of Nutrition · 65 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-06-01 · J Am Coll Nutr · vol. 21 · número 3 · págs. 250–258
- Editorial
- Taylor & Francis
- Citado
- 96 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Nutritional Studies and Diet
- Palabras clave
- dietary cholesterol, LDL/HDL ratio, premenopausal women, hyper-responders, serum cholesterol, HDL cholesterol, LDL cholesterol, apolipoprotein C-III, apolipoprotein B, cholesteryl ester transfer protein, coronary heart disease risk, ethnic differences, Hispanic women
- MeSH
- humans, coronary disease, lipids, cholesterol, dietary, apoproteins, anthropometry, analysis of variance, cross-over studies, motor activity, premenopause, blood pressure, time factors, adolescent, adult, middle aged, female, cholesterol, ldl, cholesterol, hdl, ethnicity
7 autores
- Kristin L. Herron🇺🇸 · autor de correspondenciaUniversity of Connecticut
- Sonia Vega‐López🇺🇸University of Connecticut
- Karin Conde🇺🇸Columbia University
- Tripurasundari Ramjiganesh🇺🇸University of Connecticut
- Suheeta Roy🇺🇸University of Connecticut
- Neil S. Shachter🇺🇸Columbia University
- María Luz Fernández🇺🇸University of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cholesterol is the dietary component that has elicited the most public interest in conjunction with coronary heart disease. However, the impact of excess dietary cholesterol intake on plasma cholesterol levels cannot be accurately predicted; therefore, its role in disease progression is not straightforward. Individual response variation can be due to factors such as ethnicity, hormonal status, obesity and genetic predisposition.
Objective
The purpose of this study was to evaluate the differences that occur within the plasma compartment of normolipidemic pre-menopausal women, classified based on their response to a high dietary cholesterol challenge.
Design
We recruited 51 pre-menopausal women (29 Caucasian and 22 of Hispanic origin) aged 18 to 49 years with initial plasma cholesterol concentrations ranging from 3.62 to 5.17 mmol/L. Using a cross-over research design, women were randomly allocated to an egg (640 mg additional dietary cholesterol per day) or placebo group (0 mg additional dietary cholesterol per day) initially, and the two 30 day periods were separated by a three-week washout.
Results
An initial evaluation of the ethnicity effects revealed elevations in both plasma LDL-C (p or =0.06 mmol/L increase in total blood cholesterol per each additional 100 mg of dietary cholesterol consumed per day), based on their reaction to the additional dietary cholesterol provided. Hypo-responders did not experience an increase in LDL-C or HDL-C during the egg period, while both lipoproteins were elevated in hyper-responders. However, the LDL/HDL ratio, an important parameter of coronary heart disease risk, was maintained for all subjects during the egg period independent of response. Furthermore, hyper-responders had higher concentrations of apo C-III (p < 0.001), apo B (p < 0.001) and cholesterol ester transfer protein (CETP) (p < 0.05) during this period.
Conclusion
These data revealed that excess dietary cholesterol does not increase the risk of developing an atherogenic lipoprotein profile in pre-menopausal women, regardless of their response classification. Although the addition of 640 mg of cholesterol to the diet did result in an increase in plasma cholesterol in hyperresponders, the LDL/HDL ratio was maintained. This result, accompanied by increases in CETP activity, leads to the speculation that hyper-responders may process the excess cholesterol in the plasma compartment through an enhancement of the reverse cholesterol transport pathway. With this mechanism identified, further measurement of additional parameters is needed to verify this conclusion.
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