Changes in human muscle transverse relaxation following short-term creatine supplementation
Saab G, Marsh GD, Casselman MA, Thompson RT
Experimental physiology · 10 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-05-01 · Exp Physiol · vol. 87 · número 3 · págs. 383–389
- Editorial
- Wiley
- Citado
- 20 citas · más que el 64% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Advanced MRI Techniques and Applications · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, creatine monohydrate, skeletal muscle, T2 relaxation, intracellular water, water compartments, phosphocreatine, ATP, phosphorus magnetic resonance spectroscopy, flexor digitorum profundus, weight gain, water retention
- MeSH
- muscle, skeletal, body fluids, humans, body weight, creatine, magnetic resonance imaging, muscle relaxation, dietary supplements, adult, male
4 autores
- George Saab🇨🇦Western University; Lawson Health Research Institute; St Joseph's Health Care
- Greg D. Marsh🇨🇦 · autor de correspondenciaWestern University; Lawson Health Research Institute; St Joseph's Health Care
- Mark A. Casselman🇨🇦Western University; Lawson Health Research Institute
- R. Terry Thompson🇨🇦Western University; Lawson Health Research Institute; St Joseph's Health Care
Resumen
El texto original del estudio, en el idioma en que se publicó.
The rapid increase in body mass that often occurs following creatine (Cr) supplementation is believed to be due to intracellular water retention. The purpose of this study was to determine whether Cr consumption alters the magnetic resonance (MR) transverse relaxation (T(2)) distribution of skeletal muscle. Transverse relaxation can be used to model water compartments within a cell or tissue. In this double-blind study, subjects were asked to supplement their normal diet with creatine monohydrate (20 g day(-1) for 5 days) mixed with a grape drink (Creatine group, n = 7), or the grape drink alone (Placebo group, n = 8). Phosphorous MR spectroscopy was used to determine the effectiveness of the supplementation protocol. Subjects that responded to the Cr supplementation (i.e. showed a > 5 % increase in the ratio of the levels of phosphocreatine (PCr) and ATP) were placed in the Creatine group. Both proton MR imaging and spectroscopy were used to acquire T(2) data, at 1.89 T, from the flexor digitorum profundus muscle of each subject before and after supplementation. Following the supplementation period, the Creatine group showed a gain in body mass (1.2 +/- 0.8 kg, P 5 ms) at approximately 20, 40 and 125 ms in both groups. Only in the Creatine group was there an increase in the apparent proton concentration of the two shorter components combined (+5.0 +/- 4.7 %, P < 0.05). According to the cellular water compartment model, the changes observed in the shorter T(2) components are consistent with an increase in intracellular water.
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