Caffeine affects cardiovascular and neuroendocrine activation at work and home
Lane JD, Pieper CF, Phillips-Bute BG, Bryant JE, Kuhn CM
Psychosomatic medicine · 47 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL51634)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2002-07-01 · Psychosom Med · vol. 64 · número 4 · págs. 595–603
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 117 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Sleep and Work-Related Fatigue
- Palabras clave
- caffeine, ambulatory blood pressure, heart rate, urinary catecholamines, epinephrine, norepinephrine, cortisol, stress reactivity, sympathoadrenal system, coffee consumption, coronary heart disease risk
- MeSH
- pituitary-adrenal system, hypothalamo-hypophyseal system, humans, hypertension, epinephrine, norepinephrine, catecholamines, caffeine, hydrocortisone, central nervous system stimulants, chromatography, high pressure liquid, cross-over studies, double-blind method, heart rate, dose-response relationship, drug, adult, middle aged, workplace, female, male
5 autores
- James D. Lane🇺🇸 · autor de correspondenciaDuke University; Duke Medical Center
- Carl F. Pieper🇺🇸Duke University; Duke Medical Center
- Barbara G. Phillips-Bute🇺🇸Duke University; Duke Medical Center
- John E. Bryant🇺🇸Duke University; Duke Medical Center
- Cynthia M. Kuhn🇺🇸Duke University; Duke Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate, urinary excretion of epinephrine, norepinephrine, and cortisol, and subjective measures of stress during normal activities at work and at home in the evening.
Methods
Healthy, nonsmoking, habitual coffee drinkers (N = 47) participated in 3 days of ambulatory study. After a day of ad lib caffeine consumption, caffeine (500 mg) and placebo were administered double-blind in counter-balanced order on separate workdays. Ambulatory blood pressure and heart rate were monitored from the start of the workday until bedtime. Urinary excretion of catecholamines and cortisol was assessed during the workday and evening.
Results
Caffeine administration significantly raised average ambulatory blood pressure during the workday and evening by 4/3 mm Hg and reduced average heart rate by 2 bpm. Caffeine also increased by 32% the levels of free epinephrine excreted during the workday and the evening. In addition, caffeine amplified the increases in blood pressure and heart rate associated with higher levels of self-reported stress during the activities of the day. Effects were undiminished through the evening until bedtime.
Conclusions
Caffeine has significant hemodynamic and humoral effects in habitual coffee drinkers that persist for many hours during the activities of everyday life. Furthermore, caffeine may exaggerate sympathetic adrenal-medullary responses to the stressful events of normal daily life. Repeated daily blood pressure elevations and increases in stress reactivity caused by caffeine consumption could contribute to an increased risk of coronary heart disease in the adult population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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