The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
Jee SH, Miller ER, Guallar E, Singh VK, Appel LJ, Klag MJ
American journal of hypertension · 184 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (K08 HL03857); National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK 02856)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2002-08-01 · Am J Hypertens · vol. 15 · número 8 · págs. 691–696
- Editorial
- Oxford University Press
- Citado
- 346 citas · más que el 60% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- magnesium supplementation, blood pressure, hypertension, dose-response relationship, systolic blood pressure, diastolic blood pressure, dietary magnesium, antihypertensive effect
- MeSH
- humans, hypertension, magnesium, analysis of variance, confidence intervals, double-blind method, blood pressure, dose-response relationship, drug, adult, aged, middle aged, female, male, randomized controlled trials as topic
6 autores
- Sun Ha Jee🇰🇷Yonsei University
- Edgar R. Miller🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine
- Eliseo Güallar🇺🇸Johns Hopkins University
- Vikesh K. Singh🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Lawrence J. Appel🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- M J Klag🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design.
Methods
We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose-response relationship of magnesium to BP.
Results
The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were -0.6 (-2.2 to 1.0) mm Hg for systolic BP and -0.8 (-1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2; P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0; P = .09) for each 10 mmol/day increase in magnesium dose.
Conclusions
Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.
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