Influence of dietary cholesterol on vitamin d metabolism in formula-fed preterm neonates
Picaud JC, Boucher P, Lapillonne A, Berthouze M, Delvin E, Boehm G, Claris O, Laborie S, Reygrobellet B, Lapillonne H, Glorieux FH, Salle BL
Journal of pediatric gastroenterology and nutrition · 4 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Marcadores de salud y funcionamiento
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Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2002-08-01 · J Pediatr Gastroenterol Nutr · vol. 35 · número 2 · págs. 180–184
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 6 citas · más que el 64% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Infant Nutrition and Health · Neonatal skin health care
- Palabras clave
- dietary cholesterol, vitamin D metabolism, preterm infants, preterm formula, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, cytochrome P450, HMG-CoA reductase, cholesterol supplementation
- MeSH
- milk, human, humans, cholesterol, hydroxymethylglutaryl coa reductases, cholesterol, dietary, vitamin d, rna, messenger, bottle feeding, prospective studies, infant food, infant, newborn, infant, premature, infant nutritional physiological phenomena
12 autores
- Jean‐Charles Picaud🇫🇷 · autor de correspondenciaHôpital Edouard Herriot
- Philippe Boucher🇫🇷Hôpital Edouard Herriot
- Alexandre Lapillonne🇫🇷Hôpital Edouard Herriot
- Magali Berthouze🇫🇷Hôpital Edouard Herriot
- Edgar Delvin🇨🇦Shriners Hospitals for Children - Canada
- Günther Boehm🇨🇦Shriners Hospitals for Children - Canada
- Oliver Claris🇫🇷Hôpital Edouard Herriot
- Sophie Laborie🇫🇷Hôpital Edouard Herriot
- Bernadette Reygrobellet🇫🇷Hôpital Edouard Herriot
- Hélène Lapillonne🇫🇷Hôpital Edouard Herriot
- Francis H. Glorieux🇨🇦Shriners Hospitals for Children - Canada
- Bernard Louis Salle🇫🇷Hôpital Edouard Herriot
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Supplementation of preterm formulas with cholesterol could help to mimic the fat composition of human milk. However, this could possibly influence vitamin D 25-hydroxylation because this reaction is catalyzed in part by the mitochondrial cytochrome P-450, the enzyme responsible for the 27-hydroxylation of cholesterol. The purpose of this study was to verify whether the addition of cholesterol to preterm formulas could interfere with vitamin D metabolism in preterm neonates.
Methods
In a prospective study, 30 preterm neonates were randomly assigned to a low (< 0.03 g/L), medium (0.15 g/L), or high (0.30 g/L) cholesterol-content preterm formula until theoretical term (i.e., 40 weeks post-conceptional age). Anthropometric data and serum hydroxy-vitamin D and 1,25 dihydroxy-vitamin D concentrations were measured at study entry and theoretical term. In a subgroup of 14 subjects, serum cholesterol and lymphocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA were also assessed.
Results
(median [25, 75 centiles]): At theoretical term, there were no significant differences in serum hydroxy-vitamin D concentrations among the three groups, even after adjustment for confounding variables (65 [50, 78] nmol/L, 79 [59, 86] nmol/L, and 67 [43, 103] nmol/L, respectively, = 0.65) or 1,25 dihydroxy-vitamin D ( = 0.88). Furthermore, there were no significant differences in 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA copy numbers.
Conclusions
In preterm neonates fed formulas with a cholesterol content similar to or higher than that of human milk, we did not observe deleterious effects on vitamin D metabolism. However, long-term effects of cholesterol supplementation require further studies.
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