Central and peripheral effects of sustained caffeine use: tolerance is incomplete
Watson J, Deary I, Kerr D
British journal of clinical pharmacology · 32 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-10-01 · Br J Clin Pharmacol · vol. 54 · número 4 · págs. 400–406
- Editorial
- Wiley
- Citado
- 47 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Blood Pressure and Hypertension Studies
- Palabras clave
- caffeine, caffeine tolerance, middle cerebral artery blood flow velocity, cerebral blood flow, systolic blood pressure, mood, cognitive performance, normoglycemia
- MeSH
- middle cerebral artery, humans, caffeine, central nervous system stimulants, blood flow velocity, cross-over studies, double-blind method, affect, cognition, psychometrics, blood pressure, adult
3 autores
- Joanne Watson🇬🇧Royal Bournemouth Hospital
- Ian J. Deary🇬🇧University of Edinburgh
- David Kerr🇬🇧 · autor de correspondenciaRoyal Bournemouth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
It is widely held that tolerance develops to the effects of sustained caffeine consumption. This study was designed to investigate the effects of chronic, staggered caffeine ingestion on the responses of an acute caffeine challenge, during -euglycaemia.
Methods
Twelve healthy volunteers were randomized using a double-blind, cross-over design to take either 200 mg caffeine (C-replete) or placebo (C-naïve) twice daily for 1 week. Following baseline measurements being made, the responses to 200 mg caffeine (blood-pressure, middle cerebral artery velocity, mood and cognitive performance) were examined over the subsequent 120 min. Blood glucose was not allowed to fall below 4.0 mmol l-1.
Results
After the caffeine challenge, middle cerebral artery blood velocity decreased in both conditions but was greater in the C-naïve condition (-8.0 [-10.0, -6.1] cm s-1 vs -4.9 [-6.8, -2.9] cm s-1 C-replete, P < 0.02). Systolic blood pressure rise was not significantly different in C-naïve, although this rise was more sustained over time (P < 0.04). Mood was adversely affected by regular caffeine consumption with tense aspect of mood significantly higher at baseline in C-replete 11.6 +/- 0.6 C-naïve vs 16.3 +/- 1.6 C-replete, P < 0.01). Cognitive performance was not affected by previous caffeine exposure.
Conclusions
Overall these results suggest that tolerance is incomplete with respect to both peripheral or central effects of caffeine.
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