Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension
Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ
The American journal of clinical nutrition · 221 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-11-01 · Am J Clin Nutr · vol. 76 · número 5 · págs. 1007–1015
- Editorial
- Elsevier BV
- Citado
- 338 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Diabetes Treatment and Management · Nutritional Studies and Diet
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, type 2 diabetes, hypertension, glycemic control, fasting blood glucose, insulin sensitivity, insulin secretion, blood pressure, serum lipids, HDL cholesterol, triglycerides, olive oil
- MeSH
- humans, hypertension, diabetes mellitus, type 2, insulin, blood glucose, lipids, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, lipoproteins, phospholipids, plant oils, blood pressure monitoring, ambulatory, double-blind method, blood pressure, heart rate, aged, middle aged, female, male, olive oil
6 autores
- Richard John Woodman🇦🇺The University of Western Australia; Royal Perth Hospital
- Trevor Anthony Mori🇦🇺The University of Western Australia; Royal Perth Hospital
- Valerie Burke🇦🇺The University of Western Australia; Royal Perth Hospital
- Ian B. Puddey🇦🇺The University of Western Australia; Royal Perth Hospital
- Gerald F. Watts🇦🇺The University of Western Australia; Royal Perth Hospital
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
n-3 Fatty acids lower blood pressure, improve lipids, and benefit other cardiovascular disease risk factors. Effects on glycemia in patients with type 2 diabetes are uncertain.
Objective
We determined whether purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have differential effects on glycemic control, including insulin sensitivity and stimulated insulin secretion; 24-h ambulatory blood pressure; and serum lipids in type 2 diabetic patients with treated hypertension.
Design
In a double-blind, placebo-controlled trial of parallel design, 59 subjects were randomly assigned to consume 4 g EPA, DHA, or olive oil/d for 6 wk while continuing to consume their usual diet.
Results
Thirty-nine men and 12 postmenopausal women with a mean (+/- SE) age of 61.2 +/- 1.2 y completed the study. In comparison with the change from baseline in fasting glucose in the olive oil group, fasting glucose in the EPA and DHA groups increased 1.40 +/- 0.29 mmol/L (P = 0.002) and 0.98 +/- 0.29 mmol/L (P = 0.002), respectively. Neither EPA nor DHA had significant effects on glycated hemoglobin, fasting insulin or C-peptide, insulin sensitivity or secretion, or blood pressure. Serum triacylglycerols in the EPA and DHA groups decreased 19% (P = 0.022) and 15% (P = 0.022), respectively. There were no significant changes in serum total, LDL, or HDL cholesterol, although HDL(2) cholesterol in the EPA and DHA groups increased 16% (P = 0.026) and 12% (P = 0.05), respectively. HDL(3) cholesterol decreased 11% (P = 0.026) with EPA supplementation.
Conclusions
EPA and DHA had similar benefits on lipids but adverse effects on short-term glycemic control in hypertensive diabetic patients. The overall implications for cardiovascular disease require long-term evaluation.
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