Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans
Verhoef P, Pasman WJ, Van Vliet T, Urgert R, Katan MB
The American journal of clinical nutrition · 99 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-12-01 · Am J Clin Nutr · vol. 76 · número 6 · págs. 1244–1248
- Editorial
- Elsevier BV
- Citado
- 159 citas · más que el 95% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Folate and B Vitamins Research · Alcohol Consumption and Health Effects
- Palabras clave
- caffeine, coffee, homocysteine, hyperhomocysteinemia, cardiovascular risk, plasma homocysteine, sex differences, caffeine metabolism, filtered coffee
- MeSH
- humans, vitamin b 12, caffeine, vitamin b 6, homocysteine, placebos, fasting, cross-over studies, sex characteristics, coffee, adult, aged, middle aged, female, male
5 autores
- Petra Verhoef🇳🇱Wageningen University & Research
- Wilrike J. Pasman
- Trinette van Vliet
- Rob Urgert B
- Mira Katan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown.
Objective
The objective was to determine whether caffeine explains the homocysteine-raising effect of coffee.
Design
Forty-eight subjects aged 19-65 y completed this randomized crossover study with 3 treatments, each lasting 2 wk. Subjects consumed 6 capsules providing 870 mg caffeine/d (test treatment), 0.9 L paper-filtered coffee providing approximately 870 mg caffeine/d, or 6 placebo capsules. Blood samples were drawn fasting and 4 h after consumption of 0.45 L coffee or 3 capsules.
Results
The mean fasting plasma homocysteine concentration after the placebo treatment was 9.6 +/- 3.1 micro mol/L. The caffeine and coffee treatments increased fasting homocysteine by 0.4 micro mol/L (95% CI: 0.1, 0.7; P = 0.04), or 5%, and by 0.9 micro mol/L (95% CI: 0.6, 1.2; P = 0.0001), or 11%, respectively, compared with placebo. The increase in homocysteine concentrations 4 h after consumption of 0.45 L coffee relative to consumption of 3 placebo capsules was 19% (P = 0.0001). Caffeine treatment had a much weaker acute effect on homocysteine (4%; P = 0.09). Effects of caffeine were stronger in women than in men, but the effects of coffee did not differ significantly between men and women.
Conclusions
Caffeine is partly responsible for the homocysteine-raising effect of coffee. Coffee, but not caffeine, affects homocysteine metabolism within hours after intake, although the effect is still substantial after an overnight fast.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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