Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients
Woodman RJ, Mori TA, Burke V, Puddey IB, Barden A, Watts GF, Beilin LJ
Atherosclerosis · 151 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Health and Medical Research Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2002-12-27 · Atherosclerosis · vol. 166 · número 1 · págs. 85–93
- Editorial
- Elsevier BV
- Citado
- 199 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Platelet Disorders and Treatments · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, type 2 diabetes, hypertension, platelet aggregation, fibrinolysis, thromboxane B2, von Willebrand factor, P-selectin, flow-mediated dilation, nitroglycerin, atherothrombosis, olive oil placebo, anti-thrombotic effects
- MeSH
- endothelium, vascular, humans, hypertension, diabetes mellitus, type 2, docosahexaenoic acids, eicosapentaenoic acid, double-blind method, fibrinolysis, platelet aggregation, adult, aged, middle aged, female, male
7 autores
- Richard John Woodman🇦🇺The University of Western Australia; Royal Perth Hospital
- Trevor Anthony Mori🇦🇺The University of Western Australia; Royal Perth Hospital
- Valerie Burke🇦🇺The University of Western Australia; Royal Perth Hospital
- Ian B. Puddey🇦🇺The University of Western Australia; Royal Perth Hospital
- Anne E. Barden🇦🇺The University of Western Australia; Royal Perth Hospital
- Gerald F. Watts🇦🇺The University of Western Australia; Royal Perth Hospital
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Type 2 diabetes and hypertension are both associated with an increased risk of atherothrombosis. We assessed whether purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil have differential effects on platelet, fibrinolytic and vascular function in patients with both conditions.
Methods
In a double-blind placebo-controlled trial of parallel design, 59 treated-hypertensive Type 2 diabetic men and postmenopausal women, were randomised to 4 g/day of EPA, DHA or olive oil (placebo) for 6 weeks. Collagen and PAF-stimulated platelet aggregation, collagen-stimulated thromboxane release (TXB2), plasma tPA and PAI-1 antigens, von Willebrand factor, p-selectin, and flow-mediated and glyceryl-trinitrate-mediated dilatation of the brachial artery, were examined before and at the end of intervention.
Results
Thirty-nine men and 12 women aged 61.2+/-1.2 year completed the study. Relative to placebo, DHA but not EPA supplementation significantly reduced collagen aggregation (16.9%, P=0.05) and TXB2 (18.8%, P=0.03). There were no significant changes in either PAF-stimulated platelet aggregation, fibrinolytic function or vascular function in either the EPA or DHA group relative to placebo.
Conclusion
Highly purified DHA may be a more effective anti-thrombotic agent than EPA. However, longer-term studies assessing morbidity and mortality are needed in order to establish if DHA contributes to reducing CHD amongst Type 2 diabetic patients with treated hypertension.
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