Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ
The American journal of clinical nutrition · 891 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-01-01 · Am J Clin Nutr · vol. 77 · número 1 · págs. 204–210
- Editorial
- Elsevier BV
- Citado
- 1,396 citas · más que el 100% de estudios similares · 27.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 22 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D3, vitamin D, 25-hydroxyvitamin D3, vitamin D requirements, oral vitamin D supplementation, dose-response relationship, cutaneous vitamin D synthesis, vitamin D deficiency
- MeSH
- humans, calcium, cholecalciferol, calcifediol, administration, oral, seasons, dose-response relationship, drug, adult, nebraska, male
5 autores
- Robert P. Heaney🇺🇸 · autor de correspondenciaBoston University; Creighton University
- K. Michael Davies🇺🇸Boston University; Creighton University
- Tai C. Chen🇺🇸Boston University; Creighton University
- Michael F. Holick🇺🇸Boston University; Creighton University
- M. Janet Barger-Lux🇺🇸Boston University; Creighton University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin.
Objectives
The objectives were to establish the quantitative relation between steady state cholecalciferol input and the resulting serum 25-hydroxycholecalciferol concentration and to estimate the proportion of the daily requirement during winter that is met by cholecalciferol reserves in body tissue stores.
Design
Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25, 125, and 250 micro g cholecalciferol for approximately 20 wk during the winter to 67 men living in Omaha (41.2 degrees N latitude). The time course of serum 25-hydroxycholecalciferol concentration was measured at intervals over the course of treatment.
Results
From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of approximately 0.70 nmol/L for each additional 1 micro g cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 micro g (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting 25-hydroxycholecalciferol concentration was estimated at approximately 96 micro g (approximately 3800 IU)/d. By difference, the tissue stores provided approximately 78-82 micro g/d.
Conclusions
Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting > 80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
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