Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study
Bruera E, Strasser F, Palmer JL, Willey J, Calder K, Amyotte G, Baracos V
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 152 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2002-12-28 · J Clin Oncol · vol. 21 · número 1 · págs. 129–134
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 287 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutrition and Health in Aging · Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology
- Palabras clave
- fish oil, advanced cancer, anorexia, cachexia, appetite, weight loss, eicosapentaenoic acid, docosahexaenoic acid, nutritional status, energy intake, fatigue, nausea, dysphagia, omega-3 fatty acids
- MeSH
- humans, neoplasms, cachexia, anorexia, fish oils, statistics, nonparametric, double-blind method, dietary supplements, middle aged, female, male
7 autores
- Eduardo D Bruera🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- Florian Strasser🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- J. Lynn Palmer🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- Jie S. Willey🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- Kathryn Calder🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- G. Amyotte🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
- Vickie Elaine Baracos🇺🇸🇨🇦The University of Texas MD Anderson Cancer Center; University of Alberta; Grey Nuns Community Hospital; Cross Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To determine whether high doses of fish oil, administered over 2 weeks, improve symptoms in patients with advanced cancer and decreased weight and appetite.
Patients and methods
Sixty patients were randomly assigned to fish oil capsules or placebo. Appetite, tiredness, nausea, well-being, caloric intake, nutritional status, and function were prospectively assessed at days 1 and 14.
Results
The baseline weight loss was 16 +/- 11 and 16 +/- 8 kg in the fish oil (n = 30) and placebo (n = 30) group respectively, whereas the baseline appetite (0 mm = best and 10 mm = worst) was 58 +/- 24 mm and 67 +/- 19 mm, respectively (P = not significant). The mean daily dose was 10 +/- 4 (fish oil group) and 9 +/- 3 (placebo group) capsules, which provided 1.8 g of eicosapentaenoic acid and 1.2 g of docosahexaenoic acid in the fish oil group. No significant differences in symptomatic or nutritional parameters were found (P <.05), and there was no correlation between changes in different variables between days 1 and 14 and the fish oil doses. Finally, the majority of the patients were not able to swallow more than 10 fish oil capsules per day, mainly because of burping and aftertaste.
Conclusion
Fish oil did not significantly influence appetite, tiredness, nausea, well-being, caloric intake, nutritional status, or function after 2 weeks compared with placebo in patients with advanced cancer and loss of both weight and appetite.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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