Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans
Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P
Journal of applied physiology (Bethesda, Md. : 1985) · 44 citas
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Publicación
- Publicado
- 2003-05-01 · J Appl Physiol (1985) · vol. 94 · número 5 · págs. 1910–1916
- Editorial
- American Physiological Society
- Citado
- 87 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Metabolism, Diabetes, and Cancer
- Palabras clave
- creatine supplementation, protein supplementation, GLUT4, skeletal muscle glucose transport, muscle glycogen, resistance training, immobilization, glucose tolerance, oral glucose tolerance test, vastus lateralis
- MeSH
- muscle fibers, fast-twitch, muscle fibers, slow-twitch, muscle, skeletal, humans, body weight, creatine, glycogen, glucose, blood glucose, monosaccharide transport proteins, muscle proteins, dietary proteins, glucose tolerance test, cell count, double-blind method, immobilization, muscle contraction, physical fitness, adolescent, adult, female, male, glucose transporter type 4, functional laterality
7 autores
- Wim Derave🇧🇪KU Leuven
- Bert O. Eijnde🇧🇪KU Leuven
- Patricia Verbessem🇧🇪KU Leuven
- Monique Ramaekers🇧🇪KU Leuven
- Mark FM Van Leemputte🇧🇪KU Leuven
- Erik Arne Richter🇩🇰University of Copenhagen; Copenhagen Muscle Research Centre
- Peter Hespel🇧🇪KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
The present study was undertaken to explore the effects of creatine and creatine plus protein supplementation on GLUT-4 and glycogen content of human skeletal muscle. This was investigated in muscles undergoing a decrease (immobilization) and subsequent increase (resistance training) in activity level, compared with muscles with unaltered activity pattern. A double-blind, placebo-controlled trial was performed by 33 young healthy subjects. The subjects' right legs were immobilized with a cast for 2 wk, followed by a 6-wk resistance training program for the right knee extensor muscles. The participants were supplemented throughout the study with either placebo (Pl group) or creatine (Cr group) or with creatine during immobilization and creatine plus protein during retraining (Cr+P group). Needle biopsies were bilaterally taken from the vastus lateralis. GLUT-4 protein expression was reduced by the immobilization in all groups (P < 0.05). During retraining, GLUT-4 content increased (P < 0.05) in both Cr (+24%) and Cr+P (+33%), which resulted in higher posttraining GLUT-4 expression compared with Pl (P < 0.05). Compared with Pl, muscle glycogen content was higher (P < 0.05) in the trained leg in both Cr and Cr+P. Supplements had no effect on GLUT-4 expression or glycogen content in contralateral control legs. Area under the glucose curve during the oral glucose tolerance test was decreased from 232 +/- 23 mmol. l(-1). min(-1) at baseline to 170 +/- 23 mmol. l(-1). min(-1) at the end of the retraining period in Cr+P (P < 0.05), but it did not change in Cr or Pl. We conclude that creatine intake stimulates GLUT-4 and glycogen content in human muscle only when combined with changes in habitual activity level. Furthermore, combined protein and creatine supplementation improved oral glucose tolerance, which is supposedly unrelated to the changes in muscle GLUT-4 expression.
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