Does inflammation or undernutrition explain the low cholesterol-mortality association in high-functioning older persons? MacArthur studies of successful aging
Hu P, Seeman TE, Harris TB, Reuben DB
Journal of the American Geriatrics Society · 24 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Vermont
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-01-01 · J Am Geriatr Soc · vol. 51 · número 1 · págs. 80–84
- Editorial
- Wiley
- Citado
- 43 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Nutrition and Health in Aging
- Palabras clave
- hypocholesterolemia, total cholesterol, mortality, inflammation, malnutrition, C-reactive protein, interleukin-6, albumin, sex differences, confounding, cardiovascular risk factors, successful aging, older adults
- MeSH
- humans, nutrition disorders, inflammation, cholesterol, serum albumin, body mass index, geriatric assessment, cause of death, logistic models, risk factors, epidemiologic studies, prospective studies, health status, aged, female, male
4 autores
- Peifeng Hu🇺🇸 · autor de correspondenciaUniversity of California, Los Angeles
- Teresa E. Seeman🇺🇸University of California, Los Angeles
- Tamara B. Harris🇺🇸National Institutes of Health; National Institute on Aging
- David B. Reuben🇺🇸University of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To explore the effect of inflammation and undernutrition on the association between hypocholesterolemia and higher overall mortality in high-functioning older persons.
Design
Prospective cohort study.
Setting
Three U.S. communities.
Participants
A cohort of 870 participants from the MacArthur Studies of Successful Aging.
Measurements
Baseline information was obtained for serum levels of cholesterol, C-reactive protein, interleukin-6, and albumin; body mass index; prevalent medical conditions; health behaviors; and medications. Crude and multivariate logistic regression analyses were used to examine the association between serum total cholesterol levels and 7-year all-cause mortality, while adjusting for potential confounders.
Results
In univariate analysis, the risk ratio of low serum total cholesterol level (<169 mg/dL) for 7-year total mortality was 1.90 (95% confidence interval (CI) = 1.18-3.07). The multiple adjusted risk ratios were 1.82 (95% CI = 1.10-3.00) after controlling for markers of inflammation and nutrition and 1.39 (95% CI = 0.80-2.40) after adjustment for additional cardiovascular risk factors. Sex was an important confounding variable that contributed to the observed inverse association between low serum cholesterol and overall mortality in univariate analysis.
Conclusions
Hypocholesterolemia is not an independent risk factor for increased overall mortality in high-functioning community-dwelling older men and women. The association between low total cholesterol and high mortality observed in crude analysis is mainly confounded by common cardiovascular risk factors, rather than underlying inflammation or undernutrition.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.