A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS)
Latham NK, Anderson CS, Lee A, Bennett DA, Moseley A, Cameron ID, Fitness Collaborative Group
Journal of the American Geriatrics Society · 284 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-02-20 · J Am Geriatr Soc · vol. 51 · número 3 · págs. 291–299
- Editorial
- Wiley
- Citado
- 462 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Frailty in Older Adults · Balance, Gait, and Falls Prevention · Nutrition and Health in Aging
- Palabras clave
- frail elderly, vitamin D supplementation, home-based exercise, falls, physical performance, musculoskeletal injuries, vitamin D deficiency, physical health
- MeSH
- muscle, skeletal, humans, vitamin d, exercise, accidental falls, aged, aged, 80 and over, frail elderly, female, male
7 autores
- Nancy K. Latham🇺🇸🇳🇿Boston University; University of Auckland
- Craig S. Anderson🇳🇿University of Auckland
- Arier Chi-Lun Lee🇳🇿University of Auckland
- Derrick Bennett🇳🇿University of Auckland
- Anne M. Moseley🇦🇺The University of Sydney
- Ian Douglas Cameron🇦🇺The University of Sydney
- For The Fitness Collaborative Group🇳🇿University of Auckland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine the effectiveness of vitamin D and home-based quadriceps resistance exercise on reducing falls and improving the physical health of frail older people after hospital discharge.
Design
Multicenter, randomized, controlled trial with a factorial design.
Setting
Five hospitals in Auckland, New Zealand, and Sydney, Australia.
Participants
Two hundred forty-three frail older people.
Interventions
Patients were randomized to receive a single dose of vitamin D (calciferol, 300,000 IU) or placebo tablets and 10 weeks of high-intensity home-based quadriceps resistance exercise or frequency-matched visits.
Measurements
The primary endpoints were physical health according to the short-form health survey at 3 months and falls over 6 months. Physical performance and self-rated function were secondary endpoints. Assessments took place in the participants' homes at 3 and 6 months after randomization and were performed by blinded assessors.
Results
There was no effect of either intervention on physical health or falls, but patients in the exercise group were at increased risk of musculoskeletal injury (risk ratio = 3.6, 95% confidence interval = 1.5-8.0). Vitamin D supplementation did not improve physical performance, even in those who were vitamin D deficient (<12 ng/mL) at baseline.
Conclusion
Neither vitamin D supplementation nor a home-based program of high-intensity quadriceps resistance exercise improved rehabilitation outcomes in frail older people after hospitalization. There was no effect of vitamin D on physical performance, and the exercises increased the risk of musculoskeletal injury. These findings do not support the routine use of these interventions at these dosages in the rehabilitation of frail older people.
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