Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease
Shechter M, Bairey Merz CN, Stuehlinger HG, Slany J, Pachinger O, Rabinowitz B
The American journal of cardiology · 23 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-03-01 · Am J Cardiol · vol. 91 · número 5 · págs. 517–521
- Editorial
- Elsevier BV
- Citado
- 40 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 19 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications · Cardiac Imaging and Diagnostics
- Palabras clave
- oral magnesium supplementation, magnesium citrate, coronary artery disease, exercise tolerance, exercise-induced chest pain, quality of life, intracellular magnesium, endothelial function, symptom-limited exercise testing
- MeSH
- humans, coronary disease, chest pain, magnesium, exercise test, administration, oral, drug administration schedule, severity of illness index, probability, sensitivity and specificity, statistics, nonparametric, prospective studies, double-blind method, exercise tolerance, quality of life, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male
6 autores
- Michael Shechter🇺🇸🇮🇱 · autor de correspondenciaCedars-Sinai Medical Center; University of California, Los Angeles; Tel Aviv University; Sheba Medical Center
- C. Noel Bairey Merz🇺🇸Cedars-Sinai Medical Center; University of California, Los Angeles
- Hermann-Georg Stuehlinger🇦🇹Vienna General Hospital
- Joerg Slany🇦🇹Krankenanstalt Rudolfstiftung der Stadt Wien
- Otmar M. Pachinger🇦🇹Innsbruck Medical University; University Hospital Innsbruck
- Babeth Rabinowitz🇮🇱Tel Aviv University; Sheba Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies have demonstrated that magnesium supplementation improves endothelial function in patients with coronary artery disease (CAD). However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, has not been established. In a multicenter, multinational, prospective, randomized, double-blind and placebo-controlled trial, 187 patients with CAD (151 men, 36 women; mean +/- SD age 63 +/- 10 years, range 42 to 83) were randomized to receive either oral magnesium 15 mmol twice daily (Magnosolv-Granulat, total magnesium 365 mg provided as magnesium citrate) (n = 94) or placebo (n = 93) for 6 months. Symptom-limited exercise testing (Bruce protocol) and responses given on quality-of-life questionnaires were the outcomes measured. Magnesium therapy significantly increased intracellular magnesium levels ([Mg]i) in a substudy of 106 patients at 6 months compared with placebo (35.5 +/- 3.7 vs 32.6 +/- 2.9 mEq/L, p = 0.0151). Magnesium treatment significantly increased exercise duration time compared with placebo (8.7 +/- 2.1 vs 7.8 +/- 2.9 minutes, p = 0.0075), and lessened exercise-induced chest pain (8% vs 21%, p = 0.0237). Quality-of-life parameters significantly improved in the magnesium group. These findings suggest that oral magnesium supplementation in patients with CAD for 6 months results in a significant improvement in exercise tolerance, exercise-induced chest pain, and quality of life, suggesting a potential mechanism whereby magnesium could beneficially alter outcomes in patients with CAD.
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