A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy
Smuts CM, Huang M, Mundy D, Plasse T, Major S, Carlson SE
Obstetrics and gynecology · 140 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-03-01 · Obstet Gynecol · vol. 101 · número 3 · págs. 469–479
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 242 citas · más que el 99% de estudios similares · 12.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Pregnancy and preeclampsia studies
- Palabras clave
- docosahexaenoic acid, n-3 long-chain polyunsaturated fatty acids, omega-3 supplementation, third trimester, gestational age, birth weight, fetal growth, preterm birth, low birth weight, infant length, head circumference, dietary supplementation, pregnant women
- MeSH
- humans, birth weight, dietary fats, unsaturated, docosahexaenoic acids, pregnancy outcome, double-blind method, gestational age, pregnancy, pregnancy trimester, third, dietary supplements, adolescent, adult, outpatient clinics, hospital, missouri, female, obstetric labor, premature
6 autores
- Cornelius Mattheus Smuts🇺🇸 · autor de correspondenciaUniversity of Kansas Medical Center; University of Missouri–Kansas City
- Minzhao Huang🇺🇸University of Kansas Medical Center; University of Missouri–Kansas City
- David Mundy🇺🇸University of Kansas Medical Center; University of Missouri–Kansas City
- Terry Plasse🇺🇸University of Kansas Medical Center; University of Missouri–Kansas City
- Stacey Major🇺🇸University of Kansas Medical Center; University of Missouri–Kansas City
- Susan E. Carlson🇺🇸University of Kansas Medical Center; University of Missouri–Kansas City
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To hypothesize that higher intake of docosahexaenoic acid, an n-3 long chain polyunsaturated fatty acid, would increase duration of gestation and birth weight in US women.
Methods
This was a randomized, double-blind, controlled, clinical trial. Subjects were enrolled in an ambulatory clinic where they received prenatal care. This was a population-based sample. Most subjects received government assistance for medical care and most were black (73%). Subjects were enrolled between the 24th and 28th week of pregnancy and consumed docosahexaenoic acid (33 or 133 mg) from eggs until parturition. Gestational age and birth weight were the main study outcomes. Infant length and head circumference, preterm birth, and low birth weight were secondary outcomes.
Results
Eighty-three percent of subjects completed the study (291 of 350 enrolled). No subject was discontinued for an adverse event. After controlling for important predefined risk factors and confounding variables, gestation increased by 6.0 +/- 2.3 days (P =.009) in the higher docosahexaenoic acid group. Birth weight, length, and head circumference increased, but did not reach statistical significance (P =.06-.18), although the increases could be clinically important indications of enhanced intrauterine growth. No safety concerns were raised by the study.
Conclusion
Duration of gestation increased significantly when docosahexaenoic acid intake was increased during the last trimester of pregnancy. The increase in gestation was similar to that reported for interventions with much larger amounts of n-3 long chain polyunsaturated fatty acids.
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