Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old
Eijnde BO, Van Leemputte M, Goris M, Labarque V, Taes Y, Verbessem P, Vanhees L, Ramaekers M, Vanden Eynde B, Van Schuylenbergh R, Dom R, Richter EA, Hespel P
Journal of applied physiology (Bethesda, Md. : 1985) · 61 citas
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Publicación
- Publicado
- 2003-08-01 · J Appl Physiol (1985) · vol. 95 · número 2 · págs. 818–828
- Editorial
- American Physiological Society
- Citado
- 99 citas · más que el 70% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Sports Performance and Training
- Palabras clave
- creatine supplementation, exercise training, physical fitness, older men, resistance training, peak oxygen uptake, isometric strength, knee extensors, body composition, vastus lateralis, long-term follow-up
- MeSH
- knee, muscle, skeletal, humans, creatine, exercise test, histocytochemistry, administration, oral, follow-up studies, double-blind method, body composition, oxygen consumption, physical endurance, isometric contraction, time factors, physical education and training, weight lifting, physical fitness, dietary supplements, aged, middle aged, male
13 autores
- Bert O. Eijnde🇧🇪KU Leuven
- Marc Van Leemputte
- Marina Goris
- Valery Labarque
- Youri Taes
- Patricia Verbessem
- Luc Vanhees
- Monique Ramaekers
- Bart Vanden Eynde
- Reinout Van Schuylenbergh
- René Dom
- Erik Arne Richter
- Peter Hespel🇧🇪KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
effect of oral creatine supplementation (CR; 5 g/day) in conjunction with exercise training on physical fitness was investigated in men between 55 and 75 yr of age (n = 46). A double-blind randomized placebo-controlled (PL) trial was performed over a 6-mo period. Furthermore, a subgroup (n = 20) completed a 1-yr follow-up. The training program consisted of cardiorespiratory endurance training as well as moderate resistance training (2-3 sessions/wk). Endurance capacity was evaluated during a maximal incremental bicycle ergometer test, maximal isometric strength of the knee-extensor muscles was assessed by an isokinetic dynamometer, and body composition was assessed by hydrostatic weighing. Furthermore, in a subgroup (PL: n = 13; CR: n = 12) biopsies were taken from m. vastus lateralis to determine total creatine (TCr) content. In PL, 6 mo of training increased peak oxygen uptake rate (+16%; P < 0.05). Fat-free mass slightly increased (+0.3 kg; P < 0.05), whereas percent body fat slightly decreased (-1.2%; P < 0.05). The training intervention did not significantly change either maximal isometric strength or body weight. The responses were independent of CR. Still, compared with PL, TCr was increased by approximately 5% in CR, and this increase was closely correlated with initial muscle creatine content (r = -0.78; P < 0.05). After a 1-yr follow-up, muscle TCr was not higher in CR than in PL. Furthermore, the other measurements were not affected by CR. It is concluded that long-term creatine intake (5 g/day) in conjunction with exercise training does not beneficially impact physical fitness in men between 55 and 75 yr of age.
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