Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy
Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 132 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Raine Medical Research Foundation
- Organización sin fines de lucro
- Fondation pour la Recherche Médicale
- Gobierno
- Medical Research Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2003-04-01 · Clin Exp Allergy · vol. 33 · número 4 · págs. 442–448
- Editorial
- Wiley
- Citado
- 209 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Birth, Development, and Health
- Palabras clave
- omega-3 fatty acids, IL-13, cord blood cytokines, cord blood IgE, atopy, allergy prevention, maternal diet during pregnancy, erythrocyte membrane fatty acid composition, neonatal immune development
- MeSH
- erythrocyte membrane, fetal blood, humans, hypersensitivity, fatty acids, omega-3, fish oils, tumor necrosis factor-alpha, immunoglobulin e, interleukin-4, interleukin-5, interleukin-12, interleukin-13, logistic models, risk, longitudinal studies, double-blind method, pregnancy, female
7 autores
- Janet A. Dunstan🇦🇺The University of Western Australia
- Trevor Anthony Mori🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Anne E. Barden🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Lawrence Joseph Beilin🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Angie L. Taylor🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Patrick G. Holt🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Susan L. Prescott🇦🇺 · autor de correspondenciaThe Kids Research Institute Australia; The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
The epidemiological association between higher dietary n-3 polyunsaturated fatty acids (PUFA) and lower prevalence of asthma, has led to interest in the role of early dietary modification in allergic disease prevention. In this study we examined the effects of maternal n-3 (PUFA)-rich fish oil supplementation on cord blood (CB) IgE and cytokine levels in neonates at risk of developing allergic disease.
Methods
In a randomized double-blind, placebo-controlled trial, 83 atopic pregnant women received either fish oil capsules (n = 40) containing 3.7 g n-3 PUFA/day or placebo capsules (n = 43) from 20 weeks gestation until delivery. CB cytokine levels (IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, TNF-alpha and IFN-gamma) and total IgE levels were measured and compared between the two groups. Fatty acid composition of red cell membranes was analysed by gas chromatography and the relationships among PUFA, cytokine and IgE levels were examined.
Results
Maternal fish oil supplementation resulted in a significant increase in n-3 PUFA levels (P < 0.001) in neonatal erythrocyte membranes. Neonates whose mothers had fish oil supplementation had significantly lower plasma IL-13 (P < 0.05) compared to the control group. There was also a significant inverse relationship between levels of n-3 PUFA in neonatal cell membranes and plasma IL-13. There was no difference in levels of IgE and the other cytokines measured.
Conclusions
This study provides preliminary evidence that increasing neonatal n-3 PUFA levels with maternal dietary supplementation can achieve subtle modification of neonatal cytokine levels. Further assessment of immune function and clinical follow-up of these infants will help determine if there are any significant effects on postnatal immune development and expression of allergic disease.
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