Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects
Wallace FA, Miles EA, Calder PC
The British journal of nutrition · 119 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Medical Research Council
- Gobierno
- Biotechnology and Biological Sciences Research Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2003-05-01 · Br J Nutr · vol. 89 · número 5 · págs. 679–689
- Editorial
- Cambridge University Press
- Citado
- 198 citas · más que el 99% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- linseed oil, fish oil, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, dietary supplementation, mononuclear cells, lymphocyte proliferation, cytokine production, interleukin-6, TNF-α, plasma phospholipids, dose-response relationship, immune function
- MeSH
- leukocytes, mononuclear, t-lymphocyte subsets, humans, thiobarbituric acid reactive substances, alpha-linolenic acid, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, phospholipids, fish oils, alpha-tocopherol, interleukin-6, cytokines, drug administration schedule, analysis of variance, double-blind method, cell division, adolescent, adult, male
3 autores
- Fiona A. WALLACE🇬🇧University of Southampton
- Elizabeth A. Miles🇬🇧 · autor de correspondenciaUniversity of Southampton
- Philip C. Calder🇬🇧University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies on animal and human subjects have shown that greatly increasing the amount of linseed (also known as flaxseed) oil (rich in the n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid (ALNA)) or fish oil (FO; rich in the long-chain n-3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) in the diet can decrease a number of markers of immune function. The immunological effects of more modest doses of n-3 PUFA in human subjects are unclear, dose-response relationships between n-3 PUFA supply and immune function have not been established and whether ALNA has the same effects as its long-chain derivatives is not known. Therefore, the objective of the present study was to determine the effect of enriching the diet with different doses of FO or with a modest dose of ALNA on a range of functional responses of human monocytes and lymphocytes. In a randomised, placebo-controlled, double-blind, parallel study, forty healthy males aged 18-39 years were randomised to receive placebo or 3.5 g ALNA/d or 0.44, 0.94 or 1.9 g (EPA+DHA)/d in capsules for 12 weeks. The EPA:DHA ratio in the FO used was 1.0:2.5. ALNA supplementation increased the proportion of EPA but not DHA in plasma phospholipids. FO supplementation decreased the proportions of linoleic acid and arachidonic acid and increased the proportions of EPA and DHA in plasma phospholipids. The interventions did not alter circulating mononuclear cell subsets or the production of tumour necrosis factor-alpha, interleukin (IL) 1beta, IL-2, IL-4, IL-10 or interferon-gamma by stimulated mononuclear cells. There was little effect of the interventions on lymphocyte proliferation. The two higher doses of FO resulted in a significant decrease in IL-6 production by stimulated mononuclear cells. It is concluded that, with the exception of IL-6 production, a modest increase in intake of either ALNA or EPA+DHA does not influence the functional activity of mononuclear cells. The threshold of EPA+DHA intake that results in decreased IL-6 production is between 0.44 and 0.94 g/d.
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