Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing
Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC
American journal of obstetrics and gynecology · 115 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-05-01 · Am J Obstet Gynecol · vol. 188 · número 5 · págs. 1348–1353
- Editorial
- Elsevier BV
- Citado
- 189 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Maternal Mental Health During Pregnancy and Postpartum · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, omega-3 supplementation, postpartum depression, breastfeeding, plasma phospholipid fatty acids, information processing, maternal mental health
- MeSH
- humans, depression, postpartum, docosahexaenoic acids, fatty acids, phospholipids, drug administration schedule, longitudinal studies, self concept, mental processes, breast feeding, postpartum period, pregnancy, dietary supplements, adult, female, surveys and questionnaires
6 autores
- Antolin M. Llorente🇺🇸Agricultural Research Service; United States Department of Agriculture
- Craig L. Jensen🇺🇸Agricultural Research Service; Mayo Clinic; United States Department of Agriculture; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine; Texas Children's Hospital
- Robert G. Voigt🇺🇸Agricultural Research Service; Mayo Clinic; United States Department of Agriculture; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine; Texas Children's Hospital
- J. Kennard Fraley🇺🇸Agricultural Research Service; Mayo Clinic; United States Department of Agriculture; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine; Texas Children's Hospital
- Marcia C. Berretta🇺🇸Agricultural Research Service; Mayo Clinic; United States Department of Agriculture; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine; Texas Children's Hospital
- William C. Heird🇺🇸Agricultural Research Service; Mayo Clinic; United States Department of Agriculture; Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine; Texas Children's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The purpose of this study was to determine the effect of docosahexaenoic acid supplementation on plasma phospholipid docosahexaenoic acid content and indices of depression and information processing for women who breast-feed.
Study design
Mothers who planned to breast-feed their infants were assigned randomly in a double-masked fashion to receive either docosahexaenoic acid (approximately 200 mg/d) or placebo for the first 4 months after the delivery. Major outcome variables included plasma phospholipid fatty acid patterns and scores on a self-rating questionnaire of current depression symptoms. A structured clinical interview of depression, scores on another self-rating questionnaire of depression symptoms, and a laboratory measure of information processing were obtained in subgroups of the total population.
Results
Plasma phospholipid contents of docosahexaenoic acid at baseline were 3.15 +/- 0.78 and 3.31 +/- 0.70 (mg/dL of total fatty acids) in the docosahexaenoic acid and placebo groups, respectively. After 4 months, the plasma phospholipid docosahexaenoic acid content of the docosahexaenoic acid group was 8% higher (3.40 +/- 0.97 mg/dL), whereas that of the placebo group was 31% lower (2.27 +/- 0.87 mg/dL). Despite the higher plasma phospholipid docosahexaenoic acid content of the supplemented group after 4 months, there was no difference between groups in either self-rating or diagnostic measures of depression; information processing scores of the two groups also did not differ.
Conclusion
Docosahexaenoic acid supplementation ( approximately 200 mg/d) for 4 months after the delivery prevented the usual decline in plasma phospholipid docosahexaenoic acid content of women who breastfeed but did not influence self-ratings of depression, diagnostic measures of depression, or information processing.
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