Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy
Macrì A, Giuffrida S, Amico V, Iester M, Traverso CE
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 16 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-05-27 · Graefes Arch Clin Exp Ophthalmol · vol. 241 · número 7 · págs. 561–566
- Editorial
- Springer Science+Business Media
- Citado
- 27 citas · más que el 77% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ocular Surface and Contact Lens · Corneal surgery and disorders · Glaucoma and retinal disorders
- Palabras clave
- linoleic acid, gamma-linolenic acid, photorefractive keratectomy, tear secretion, ocular surface, dry eye, Schirmer test, corneal fluorescein staining, refractive surgery complications, omega-3 fatty acids, omega-6 fatty acids
- MeSH
- eye, tears, humans, refractive errors, fluorescein, alprostadil, linoleic acid, gamma-linolenic acid, prodrugs, contrast media, postoperative care, postoperative period, adult, photorefractive keratectomy, lasers, excimer, refractive surgical procedures
5 autores
- Angelo Macrì🇮🇹 · autor de correspondenciaOspedale Policlinico San Martino
- Sebastiano Giuffrida🇮🇹Fidia (Italy)
- Valentina Amico🇮🇹Fidia (Italy)
- Michele Iester🇮🇹University of Genoa
- Carlo Enrico Traverso🇮🇹University of Genoa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The aim of this study was to evaluate the effect of linoleic acid (LA) and gamma-linolenic acid (GLA), both precursors of PGE(1), on tear production, tear fluorescein clearance and on the ocular surface after photorefractive keratectomy (PRK).
Methods
Sixty subjects (age 25+/-10 years; refractive error -3+/-2 diopters (spherical equivalent), mean +/- standard deviation) undergoing PRK were enrolled. The inclusion criteria were: Schirmer 1 test >10 mm/5 min, no corneal fluorescein staining, low irritation symptoms (questionnaire score <5), standardised visual scale (to evaluate tear fluorescein clearance) score <3. Patients were randomly divided into two groups. One group of 31 subjects was treated once daily orally with tablets containing LA (28.5 mg) and GLA (15.1 mg) (from 3 days before PRK to 1 month after PRK). The control group (29 subjects) underwent PRK and received no treatment with LA and GLA. A symptoms questionnaire, Schirmer 1 test and fluorescein clearance test (FCT) using the standardised visual scale were performed before starting therapy (T(0)) and 30 days after PRK (T(1)).
Results
All patients completed the study. The Schirmer 1 test varied from 16.3+/-6.9 (T(0)) to 17.6+/-7.2 (T(1)) for the treated group and from 18.3+/-6.2 (T(0)) to 15.7+/-7.4 (T(1)) for the untreated group ( P<0.0001, two-tailed unpaired t-test). FCT was 1.9+/-0.6 at T(0) and 1.6+/-0.8 at T(1) for the treated group and 1.7+/-0.7 at T(0) and 2.0+/-0.9 at T(1) for the untreated group ( P<0.0001). The symptoms score was 4.7+/-1.9 at T(0) and 7.6+/-7.2 at T(1) for the treated group and 4.2+/-2.0 at T(0) and 10.1+/-7.6 at T(1) for the untreated group ( P<0.05).
Conclusion
Reduced corneal sensitivity has already been proved after PRK. This could be the main reason for a decrease in tear production and for a reduced blinking rate leading to delayed tear clearance. The oral precursors of PGE(1), LA and GLA, could be helpful in increasing tear production and clearance after PRK.
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