Effects of oral creatine and resistance training on myogenic regulatory factor expression
Willoughby DS, Rosene JM
Medicine and science in sports and exercise · 94 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-06-01 · Med Sci Sports Exerc · vol. 35 · número 6 · págs. 923–929
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 186 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Muscle Physiology and Disorders · Exercise and Physiological Responses
- Palabras clave
- creatine supplementation, resistance training, skeletal muscle, myogenic regulatory factors, myogenin, Myf5, myosin heavy chain, muscle protein synthesis, untrained men
- MeSH
- muscle, skeletal, humans, creatine, creatine kinase, myogenic regulatory factors, rna, messenger, placebos, administration, oral, double-blind method, gene expression regulation, weight lifting, adolescent, adult, male
2 autores
- Darryn S. Willoughby🇺🇸Texas Christian University
- John M. Rosene🇺🇸University of Hawaiʻi at Mānoa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study examined 12 wk of creatine (Cr) supplementation and heavy resistance training on skeletal muscle creatine kinase (M-CK) mRNA expression and the mRNA and protein expression of the myogenic regulatory factors Myo-D, myogenin, MFR-4, and Myf5.
Methods
Twenty-two untrained males were randomly assigned to either a control (CON), placebo (PLC), or Cr (CRT) group in a double-blind fashion. Muscle biopsies were obtained before and after training. PLC and CRT trained thrice weekly using 3 sets of 6-8 repetitions at 85-90% 1-RM on the leg press, knee extension, and knee curl exercises. CRT ingested 6 g.d-1 of Cr for 12 wk while PLC consumed the equal amount of placebo.
Results
After training, M-CK mRNA expression, as well as myogenin and MRF-4 mRNA and protein expression, were found to be significantly greater for CRT compared with PLC and CON, whereas PLC was also significantly different from CON (P 0.05). M-CK mRNA was correlated with myogenin (r = 0.916) and MRF-4 (r = 0.883) protein (P < 0.05).
Conclusion
When combined with heavy resistance training, Cr supplementation increases M-CK mRNA expression, likely due to concomitant increases in the expression of myogenin and MRF-4. Therefore, increases in myogenin and MRF-4 mRNA and protein may play a role in increasing myosin heavy chain expression, already shown to occur with Cr supplementation.
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