Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil
Ponder DL, Innis SM, Benson JD, Siegman JS
Pediatric research · 85 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-12-01 · Pediatr Res · vol. 32 · número 6 · págs. 683–687
- Editorial
- Springer Nature
- Citado
- 123 citas · más que el 99% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, term infants, infant formula, breast milk, corn oil, soybean oil, linolenic acid, phosphatidylethanolamine, plasma phospholipids, red blood cell phospholipids, infant growth
- MeSH
- erythrocytes, milk, human, humans, corn oil, docosahexaenoic acids, soybean oil, fatty acids, phospholipids, nutritional requirements, infant food, infant, newborn, infant nutritional physiological phenomena
4 autores
- Debra Ponder🇺🇸Ross Laboratories (United States)
- Sheila Margaret Innis🇨🇦🇺🇸University of British Columbia; Ross Laboratories (United States)
- John D. Benson🇨🇦🇺🇸University of British Columbia; Ross Laboratories (United States)
- Joel S. Siegman🇨🇦🇺🇸University of British Columbia; Ross Laboratories (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
The objective of this study was to compare circulating lipid docosahexaenoic acid [22:6(n-3), DHA] levels in term infants fed a powdered (CORN oil) or liquid (SOY oil) infant formula or human milk (HM). Infants whose mothers chose not to breast feed were randomly assigned to the CORN or SOY formula group. The formula fat differed in linolenic acid [18:3(n-3)] content: it was 0.8% for the CORN and 4.8% for the SOY. Linoleic acid [18:2(n-6)] was 31.5 and 34.2% fatty acids in the CORN and SOY formula, respectively. The formulas or HM were fed from birth through 8 wk of age, and growth and the plasma and red blood cell (RBC) phospholipid fatty acid composition was determined at 3 d, 4 wk, and 8 wk of age. Growth did not differ among groups. The plasma phospholipid and RBC phosphatidylethanolamine DHA was similar in the CORN and SOY formula groups at all ages. Plasma and RBC phosphatidylethanolamine levels of DHA were significantly lower in infants fed the CORN or SOY formula than in infants fed HM during wk 4 and 8. Plasma and RBC 22:5(n-6) was not increased in the formula groups at any age. The formula content of linolenic acid had no effect on the RBC or plasma DHA levels of the infants. The biologic or functional significance of the lower plasma and RBC DHA in infants fed formula rather than HM is unknown. The need for a dietary source of DHA and specificity of plasma or RBC phospholipid DHA as a measure of desaturation and elongation of linolenic acid in developing organs remains uncertain.
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