Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes
Mickleborough TD, Murray RL, Ionescu AA, Lindley MR
American journal of respiratory and critical care medicine · 157 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-08-11 · Am J Respir Crit Care Med · vol. 168 · número 10 · págs. 1181–1189
- Editorial
- American Thoracic Society
- Citado
- 232 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 79 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Fatty Acid Research and Health · Exercise and Physiological Responses
- Palabras clave
- exercise-induced bronchoconstriction, fish oil supplementation, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, elite athletes, leukotriene E4, prostaglandin F2alpha, leukotriene B4, TNF-α, IL-1β, anti-inflammatory activity, dietary intervention
- MeSH
- humans, asthma, exercise-induced, docosahexaenoic acids, eicosapentaenoic acid, respiratory function tests, severity of illness index, cross-over studies, double-blind method, sports, dietary supplements, adult, female, male
4 autores
- Timothy D. Mickleborough🇬🇧🇺🇸University Hospital of Wales; Indiana University Bloomington; University Hospital Llandough; Indiana University; Cardiff Metropolitan University
- Rachael L Murray🇬🇧🇺🇸University Hospital of Wales; Indiana University Bloomington; University Hospital Llandough; Indiana University; Cardiff Metropolitan University
- Alina Ionescu🇬🇧🇺🇸University Hospital of Wales; Indiana University Bloomington; University Hospital Llandough; Indiana University; Cardiff Metropolitan University
- Martin R. Lindley🇬🇧🇺🇸University Hospital of Wales; Indiana University Bloomington; University Hospital Llandough; Indiana University; Cardiff Metropolitan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
In elite athletes, exercise-induced bronchoconstriction (EIB) may respond to dietary modification, thereby reducing the need for pharmacologic treatment. Ten elite athletes with EIB and 10 elite athletes without EIB (control subjects) participated in a randomized, double-blind crossover study. Subjects entered the study on their normal diet, and then received either fish oil capsules containing 3.2 g eicosapentaenoic acid and 2.2 g docohexaenoic acid (n-3 polyunsaturated fatty acid [PUFA] diet; n = 5) or placebo capsules containing olive oil (placebo diet; n = 5) taken daily for 3 weeks. Diet had no effect on preexercise pulmonary function in either group or on postexercise pulmonary function in control subjects. However, in subjects with EIB, the n-3 PUFA diet improved postexercise pulmonary function compared with the normal and placebo diets. FEV1 decreased by 3 +/- 2% on n-3 PUFA diet, 14.5 +/- 5% on placebo diet, and 17.3 +/- 6% on normal diet at 15 minutes postexercise. Leukotriene (LT)E4, 9alpha, 11beta-prostaglandin F2, LTB4, tumor necrosis factor-alpha, and interleukin-1beta, all significantly decreased on the n-3 PUFA diet compared with normal and placebo diets and after the exercise challenge. These data suggest that dietary fish oil supplementation has a markedly protective effect in suppressing EIB in elite athletes, and this may be attributed to their antiinflammatory properties.
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