Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2
Ursing C, Wikner J, Brismar K, Röjdmark S
Journal of endocrinological investigation · 31 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-05-01 · J Endocrinol Invest · vol. 26 · número 5 · págs. 403–406
- Editorial
- Springer Science+Business Media
- Citado
- 43 citas · más que el 61% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Circadian rhythm and melatonin · Coffee research and impacts · Sleep and Work-Related Fatigue
- Palabras clave
- caffeine, melatonin, CYP1A2, melatonin metabolism, hepatic metabolism, serum melatonin, nocturnal melatonin, coffee consumption, drug interactions
- MeSH
- humans, melatonin, caffeine, cytochrome p-450 cyp1a2, central nervous system stimulants, capsules, reference values, female, male
4 autores
- Carina Ursing🇸🇪 · autor de correspondenciaKarolinska Institutet; Stockholm South General Hospital
- Johan Wikner🇸🇪Karolinska Institutet; Stockholm South General Hospital
- Kerstin Brismar🇸🇪Karolinska University Hospital; Karolinska Institutet
- Sven Röjdmark🇸🇪Karolinska University Hospital; Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine is metabolized in the liver by cytochrome P450(CYP)1A2. Recent findings imply that this enzyme may also be of importance for the metabolism of human melatonin (MT). If caffeine and MT are metabolized by the same enzyme, one may expect to find different serum MT levels after ingestion of coffee compared with placebo. Although coffee is consumed by people all over the world, few studies have focused on whether caffeine actually affects serum MT levels in normal subjects. We decided to study that particular topic. For that purpose 12 healthy individuals were tested on two occasions, one week apart. On one of these occasions they were given a capsule containing 200 mg caffeine in the evening. On the other, they received placebo. The experimental order was randomized. Serum MT levels were determined every second hour between 22:00 h and 08:00 h, and the melatonin areas under the curve (MT-AUCs) were calculated. After caffeine the serum MT level rose from 0.09 +/- 0.03 nmol/l at 22:00 h to 0.48 +/- 0.07 nmol/l at 04:00 h. The corresponding rise after placebo was less prominent (from 0.06 +/- 0.01 to 0.35 +/- 0.06 nmol/l). This was reflected by the MT-AUC which was 32% larger after ingestion of caffeine compared with placebo (MT-AUC(caffeine) 3.16 +/- 0.44 nmol/l x h vs MT-AUC(placebo) 2.39 +/- 0.40 nmol/l x h; p < 0.02). These findings imply that caffeine, ingested in the evening at a dose corresponding to two ordinary cups of coffee, augments the nocturnal serum MT level, which in turn supports the notion that cytochrome P450(CYP)1A2 is involved in the hepatic metabolism of human MT.
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