Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
Trebble T, Arden NK, Stroud MA, Wootton SA, Burdge GC, Miles EA, Ballinger AB, Thompson RL, Calder PC
The British journal of nutrition · 149 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Wessex Medical Research
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-08-01 · Br J Nutr · vol. 90 · número 2 · págs. 405–412
- Editorial
- Cambridge University Press
- Citado
- 228 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, TNF-α, interleukin-6, peripheral blood mononuclear cells, antioxidant supplementation, phospholipid fatty acid composition, phosphatidylcholine, phosphatidylethanolamine, lipid peroxidation, dose-response relationship, healthy men
- MeSH
- erythrocytes, monocytes, humans, malondialdehyde, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, phospholipids, fish oils, tumor necrosis factor-alpha, interleukin-6, antioxidants, double-blind method, dose-response relationship, drug, dietary supplements, adult, male
9 autores
- Timothy M Trebble🇬🇧 · autor de correspondenciaUniversity of Southampton
- Nigel Arden🇬🇧Southampton General Hospital; University of Southampton
- Mike Adrian Stroud🇬🇧University of Southampton
- Stephen A. Wootton🇬🇧University of Southampton
- Graham C. Burdge🇬🇧University of Southampton
- Elizabeth A. Miles🇬🇧University of Southampton
- Anne Ballinger🇬🇧University of London; Queen Mary University of London
- Rachel L. Thompson🇬🇧University of Southampton
- Philip C. Calder🇬🇧University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increased dietary consumption of the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (20 : 5n-3; EPA) and docosahexaenoic acid (22 : 6n-6; DHA) is associated with their incorporation into circulating phospholipid and increased production of lipid peroxide metabolites. The relationship between peripheral blood mononuclear cell (PBMC) function, n-3 PUFA intake and antioxidant co-supplementation is poorly defined. We therefore investigated tumour necrosis factor (TNF)-alpha and interleukin (IL) 6 production by PBMC and phospholipid fatty acid composition in plasma and erythrocytes of healthy male subjects (n 16) receiving supplemental intakes of 0.3, 1.0 and 2.0 g EPA+DHA/d, as consecutive 4-week courses. All subjects were randomised in a double-blind manner to receive a concurrent antioxidant supplement (200 microg Se, 3 mg Mn, 30 mg D-alpha-tocopheryl succinate, 90 mg ascorbic acid, 450 microg vitamin A (beta-carotene and retinol)) or placebo. There was a positive dose-dependent relationship between dietary n-3 PUFA intake and EPA and DHA incorporation into plasma phosphatidylcholine and erythrocyte phosphatidylethanolamine, with a tendency towards a plateau at higher levels of intake. Production of TNF-alpha and IL-6 by PBMC decreased with increasing n-3 PUFA intake but tended towards a 'U-shaped' dose response. Both responses appeared to be augmented by antioxidant co-supplementation at intermediate supplementary n-3 PUFA intakes. Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake.
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