Influence of creatine monohydrate ingestion on muscle metabolites and intense exercise capacity in individuals with multiple sclerosis
Lambert CP, Archer RL, Carrithers JA, Fink WJ, Evans WJ, Trappe TA
Archives of physical medicine and rehabilitation · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (F32 AG05873)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2003-08-01 · Arch Phys Med Rehabil · vol. 84 · número 8 · págs. 1206–1210
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 49% de estudios similares · 0.1× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Biochemical effects in animals
- Palabras clave
- creatine monohydrate, multiple sclerosis, relapsing-remitting multiple sclerosis, phosphocreatine, muscle metabolites, knee flexion and extension, vastus lateralis, dietary supplementation
- MeSH
- muscle, skeletal, humans, multiple sclerosis, creatine, phosphocreatine, biopsy, needle, disability evaluation, treatment outcome, exercise, double-blind method, ergometry, placebo effect, exercise tolerance, muscle contraction, adult, female, male
6 autores
- Charles Paul Lambert🇺🇸 · autor de correspondenciaUniversity of Arkansas for Medical Sciences
- ROBERT L. ARCHER🇺🇸University of Arkansas for Medical Sciences
- John A. Carrithers🇺🇸University of Arkansas for Medical Sciences
- William J. Fink🇺🇸University of Arkansas for Medical Sciences
- William J. Evans🇺🇸University of Arkansas for Medical Sciences
- Todd A. Trappe🇺🇸University of Arkansas for Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the effectiveness of ingesting creatine monohydrate in elevating intramuscular creatine stores and improving exercise capacity in individuals with multiple sclerosis (MS).
Design
Randomized, double-blind, placebo-controlled, pre-posttrial.
Setting
A university-based exercise physiology laboratory.
Participants
Sixteen individuals with relapsing-remitting MS (median Expanded Disability Status Scale score, 4.75; range, 1.5-6.0).
Intervention
Eight individuals with MS were randomized to the creatine group (20g/d of creatine monohydrate for 5d), and 8 others were randomized to the placebo group. Needle biopsies were performed on the vastus lateralis at rest before and after treatment. Subjects performed 3 bouts of 30 maximal knee extensions and flexions at 180 degrees /s with 1 minute of recovery between bouts before and after treatment.
Main outcome measures
Intramuscular total creatine, phosphocreatine, free creatine, and total work output.
Results
Creatine ingestion did not significantly elevate intramuscular total creatine, phosphocreatine, or free creatine or improve total work production.
Conclusion
Creatine ingestion had no significant effect on muscle creatine stores or high-intensity exercise capacity in individuals with MS.
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