Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation
Trebble TM, Wootton SA, Miles EA, Mullee M, Arden NK, Ballinger AB, Stroud MA, Burdge GC, Calder PC
The American journal of clinical nutrition · 114 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Wessex Medical Research
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-09-01 · Am J Clin Nutr · vol. 78 · número 3 · págs. 376–382
- Editorial
- Elsevier BV
- Citado
- 179 citas · más que el 98% de estudios similares · 9.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory mediators and NSAID effects · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, prostaglandin E2, T cell function, lymphocyte proliferation, interferon-gamma, IL-4, antioxidants, selenium, tocopherols, vitamin C, vitamin A, eicosapentaenoic acid, docosahexaenoic acid, dietary supplementation, peripheral blood mononuclear cells
- MeSH
- leukocytes, mononuclear, th1 cells, th2 cells, humans, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, dinoprostone, fish oils, interleukin-4, antioxidants, lymphocyte activation, dietary supplements, adult, male
9 autores
- Timothy M Trebble🇬🇧 · autor de correspondenciaUniversity of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Stephen A. Wootton🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Elizabeth A. Miles🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Mark Mullee🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Nigel Arden🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Anne Ballinger🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Mike Adrian Stroud🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Graham C. Burdge🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
- Philip C. Calder🇬🇧University of London; St Bartholomew's Hospital; Queen Mary University of London; Royal London Hospital; University of Southampton; Medical Research Council
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on interleukin 4 (IL-4) production is unclear. Fish oil, which contains eicosapentaenoic and docosahexaenoic acids, inhibits production of PGE(2). The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants.
Objective
We investigated the effect of dietary fish oil with and without antioxidant cosupplementation on lymphocyte proliferation and the production of PGE(2), IFN-gamma, and IL-4 by peripheral blood mononuclear cells.
Design
Sixteen healthy men received dietary fish-oil supplements providing 0.3, 1, and 2 g eicosapentaenoic acid plus docosahexaenoic acid/d for 4 consecutive weeks each (total of 12 wk). All subjects were randomly assigned to daily cosupplementation with either antioxidants (200 microg Se, 3 mg Mn, 30 mg RRR-alpha-tocopheryl succinate, 90 mg ascorbic acid, 450 micro g vitamin A) or placebo.
Results
Fish-oil supplementation decreased PGE(2) production and increased IFN-gamma production and lymphocyte proliferation from baseline values. Cosupplementation with antioxidants did not affect cytokine production or lymphocyte proliferation.
Conclusion
Dietary fish oil modulates production of IFN-gamma and lymphocyte proliferation in a manner consistent with decreased production of PGE(2), but this effect is not modified by antioxidant cosupplementation.
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