Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial
Malcolm CA, McCulloch DL, Montgomery C, Shepherd A, Weaver LT
Archives of disease in childhood. Fetal and neonatal edition · 100 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-08-22 · Arch Dis Child Fetal Neonatal Ed · vol. 88 · número 5 · págs. 383F–390
- Editorial
- BMJ
- Citado
- 164 citas · más que el 97% de estudios similares · 6.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Neonatal and fetal brain pathology
- Palabras clave
- docosahexaenoic acid, pregnancy, visual evoked potentials, pattern visual evoked potential, P100 latency, term infants, omega-3 fatty acids
- MeSH
- milk, human, humans, body weight, docosahexaenoic acids, fatty acids, fish oils, body height, prenatal care, prospective studies, double-blind method, photic stimulation, reaction time, evoked potentials, visual, pregnancy, dietary supplements, infant, newborn, female
1 autor
- Cari A. Malcolm🇬🇧 · autor de correspondenciaUniversity of Stirling; Glasgow Caledonian University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
To test the hypothesis that maternal docosahexaenoic acid (DHA) supplementation during pregnancy enhances maturation of the visual evoked potential (VEP) in healthy term infants.
Methods
One hundred women were supplemented with either fish oil capsules rich in DHA (n = 50) or placebo capsules (n = 50) from week 15 of pregnancy until delivery. Total fatty acids in red blood cells and plasma were measured at weeks 15, 28, and 40 of pregnancy and at delivery in umbilical cord blood. Infant visual pathway development was assessed using VEPs recorded to flash stimuli shortly after birth and to both flash and pattern-reversal stimuli at 50 and 66 weeks post-conceptional age (PCA).
Results
Maternal supplementation did not significantly elevate the level of DHA in umbilical cord blood. Moreover, there were no significant differences in any of the VEP measures observed between supplementation groups. However, maturity of the pattern-reversal VEP at 50 and 66 weeks PCA was associated with DHA status of the infants at birth. Infants with higher DHA status, both as a concentration and as a percentage of total fatty acids, showed shorter P100 peak latencies of the pattern-reversal VEP than those with lower DHA status.
Conclusions
Maternal DHA supplementation during pregnancy did not enhance VEP maturation in healthy term infants. However, these results show an association between the DHA status of infants at term and early postnatal development of the pattern-reversal VEP, suggesting that DHA status itself may influence maturation of the central visual pathways.
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