Dietary supplementation with fish oil in ulcerative colitis
Stenson WF, Cort D, Rodgers J, Burakoff R, DeSchryver-Kecskemeti K, Gramlich TL, Beeken W
Annals of internal medicine · 229 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 33165); National Center for Research Resources (RR109); National Center for Research Resources (RR.00036)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1992-04-15 · Ann Intern Med · vol. 116 · número 8 · págs. 609–614
- Editorial
- American College of Physicians
- Citado
- 392 citas · más que el 100% de estudios similares · 18.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory Bowel Disease · Inflammatory mediators and NSAID effects
- Palabras clave
- ulcerative colitis, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, leukotriene B4, prostaglandin E2, inflammatory bowel disease, prednisone dose reduction, sulfasalazine, weight gain, dietary omega-3 fatty acids, disease activity
- MeSH
- gastrointestinal contents, humans, colitis, ulcerative, prednisone, dietary fats, unsaturated, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, leukotriene b4, dinoprostone, fish oils, drug combinations, sigmoidoscopy, dialysis, double-blind method, adult, middle aged, female, male
7 autores
- William F. Stenson
- David Cort🇺🇸Washington University in St. Louis
- John B. Rodgers🇺🇸Washington University in St. Louis
- Robert B. Burakoff🇺🇸Washington University in St. Louis
- Katherine Deschryver-Kecskemeti🇺🇸Washington University in St. Louis
- Terri L. Gramlich🇺🇸Washington University in St. Louis
- Warren L. Beeken🇺🇸Washington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the efficacy of fish oil supplementation in patients with active ulcerative colitis.
Design
Multicenter, randomized, double-blind, placebo-controlled, crossover trail with 4-month treatment periods (fish oil and placebo) separated by a 1-month washout.
Setting
Four gastroenterology divisions.
Patients
Twenty-four patients with active ulcerative colitis entered the study. Five dropped out, and one was noncompliant. Eighteen patients completed the study. All patients had active disease as manifested by diarrhea and rectal inflammation.
Interventions
Treatment with prednisone and sulfasalazine was continued. Fish oil supplementation consisted of 18 Max-EPA (eicosapentaenoic acid) capsules daily (eicosapentaenoic acid, 3.24 g; and docosahexaenoic acid, 2.16 g). Placebo supplementation consisted of 18 identical capsules containing isocaloric amounts of vegetable oil.
Measurements
Patients were evaluated at study entry and after each diet period. Evaluations included a review of symptoms, flexible sigmoidoscopy, rectal biopsy, and rectal dialysis to measure prostaglandin E2 and leukotriene B4 levels.
Results
Fish oil supplementation resulted in a significant decrease in rectal dialysate levels of leukotriene B4 from 71.0 to 27.7 pg/mL (average change, -43.3 pg/mL; 95% CI, -83 to -3.6). Significant improvements were seen in acute histology index (average change, -8.5 units from a baseline of 10.5 units; CI, -12.9 to -4.2) and total histology index (average change, -8.5 units from a baseline of 14.80; CI, -13.2 to -3.8) as well as significant weight gain (average weight gain, 1.74 kg, CI, 0.94 to 2.54). No significant changes occurred in any variable during the placebo period. Seven patients received concurrent treatment with prednisone. During the fish oil supplementation period, the mean prednisone dose decreased from 12.9 mg/d to 6.1 mg/d and rose from 10.4 mg/d to 12.9 mg/d during the placebo diet period (P greater than 0.20).
Conclusions
Four months of diet supplementation with fish oil in patients with inflammatory bowel disease resulted in reductions in rectal dialysate leukotriene B4 levels, improvements in histologic findings, and weight gain.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.