Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation
Mori TA, Vandongen R, Mahanian F, Douglas A
Metabolism: clinical and experimental · 43 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-10-01 · Metabolism · vol. 41 · número 10 · págs. 1059–1067
- Editorial
- Elsevier BV
- Citado
- 53 citas · más que el 95% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Antioxidant Activity and Oxidative Stress
- Palabras clave
- fish oil supplementation, olive oil supplementation, peripheral vascular disease, plasma lipids, platelet aggregation, neutrophil function, thromboxane B2, platelet fatty acid composition, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, leukotriene B4, platelet-activating factor, LDL cholesterol, HDL2, triglycerides, atherosclerosis
- MeSH
- blood platelets, neutrophils, humans, vascular diseases, lipids, dietary fats, unsaturated, docosahexaenoic acids, eicosapentaenoic acid, leukotriene b4, thromboxane b2, triglycerides, fish oils, plant oils, administration, oral, double-blind method, food, fortified, aged, middle aged, male, cholesterol, ldl, cholesterol, hdl, olive oil
4 autores
- Trevor Anthony Mori🇦🇺 · autor de correspondenciaRoyal Perth Hospital
- Robert Vandongen🇦🇺Royal Perth Hospital
- Fariba Mahanian🇦🇺Royal Perth Hospital
- A.J. Douglas🇦🇺Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
This double-blind study was designed to examine and compare the effects of supplementing the existing diet with fish oil or olive oil on lipids and cell function in patients with peripheral vascular disease. Thirty-two patients with symptomatic and angiographically demonstrated peripheral vascular disease were screened, matched, and randomly allocated to take either 15 g/d fish oil or olive oil for 4 weeks. Fish oil reduced serum triglyceride levels by 26%, but increased total cholesterol levels due to a significant increase in both low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein-2 cholesterol (HDL2-C). There was a nonsignificant decrease in HDL3-C levels. Olive oil reduced total cholesterol levels, accountable to a significantly decrease in LDL-C levels. Serum thromboxane B2 (TXB2) levels remained unchanged following fish oil, but were significantly increased by olive oil. Urinary excretion of TXB2 and 6-keto-PGF1 alpha was unaffected by either oil supplement. Platelet aggregation, which was measured in platelet-rich plasma in response to two doses of collagen or platelet-activating factor (PAF), was significantly reduced after fish oil, but was increased by olive oil. Following fish oil, there was a significant increase in eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) levels and a decrease in arachidonic acid content of platelet phospholipids. The platelet fatty acid composition after olive oil was unchanged. Fish oil decreased neutrophil leukotriene B4 (LTB4) generation following calcium ionophore stimulation by 33%, while leukotriene B5 levels increased significantly. Neutrophil PAF production and plasma lyso-PAF were unaffected by either oil.(ABSTRACT TRUNCATED AT 250 WORDS)
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