Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial
Hawthorne AB, Daneshmend TK, Hawkey CJ, Belluzzi A, Everitt SJ, Holmes GK, Malkinson C, Shaheen MZ, Willars JE
Gut · 187 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-07-01 · Gut · vol. 33 · número 7 · págs. 922–928
- Editorial
- BMJ
- Citado
- 300 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Inflammatory Bowel Disease · Fatty Acid Research and Health · Inflammatory mediators and NSAID effects
- Palabras clave
- ulcerative colitis, fish oil supplementation, eicosapentaenoic acid, leukotriene B4, leukotriene B5, corticosteroid-sparing effect, remission, relapse, neutrophils, olive oil placebo, maintenance therapy
- MeSH
- humans, colitis, ulcerative, sulfasalazine, aminosalicylic acids, mesalamine, prednisolone, eicosapentaenoic acid, leukotriene b4, plant oils, drug therapy, combination, remission induction, prospective studies, adolescent, adult, aged, middle aged, female, male, olive oil
9 autores
- A. Barney Hawthorne🇬🇧University of Nottingham
- T K Daneshmend🇬🇧University of Nottingham
- C J Hawkey🇬🇧University of Nottingham
- Andrea Belluzzi🇬🇧University of Nottingham
- S J Everitt🇬🇧University of Nottingham
- G. K. T. Holmes🇬🇧University of Nottingham
- C Malkinson🇬🇧University of Nottingham
- M Z Shaheen🇬🇧University of Nottingham
- J E Willars🇬🇧University of Nottingham
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of fish oil on the course of ulcerative colitis was investigated in a randomised blinded controlled study. Eighty seven patients received supplements of 20 ml HiEPA fish oil as triglyceride (4.5 g of eicosapentaenoic acid) or olive oil placebo daily for one year. The oils were given in addition to standard drug therapy and trial entry was stratified for disease activity. Fish oil significantly increased the eicosapentaenoic acid content of rectal mucosa to 3.2% of total fatty acids at six months, compared with 0.63% for patients on olive oil. This was associated with increased synthesis of leukotriene B5, and 53% suppression of leukotriene B4 synthesis by ionophore--stimulated neutrophils. Leukotriene B4 suppression persisted for at least two months after treatment was stopped. Treatment with fish oil resulted in measurable, but only limited clinical benefit. For patients entering the trial in relapse (n = 53), there was a significant reduction in corticosteroid requirement after one and two months treatment. There was a trend towards achieving remission (off corticosteroids) faster in the patients on fish oil, although differences were not significant. For patients in remission at trial entry or during the trial (n = 69), there was no significant difference in the rate of relapse by log rank analysis. We conclude that fish oil supplementation produces a modest corticosteroid sparing effect in active disease, but there is no benefit in maintenance therapy.
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