Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal
Laurienti PJ, Field AS, Burdette JH, Maldjian JA, Yen YF, Moody DM
AJNR. American journal of neuroradiology · 47 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-09-01 · AJNR Am J Neuroradiol · vol. 24 · número 8 · págs. 1607–11
- Editorial
- National Institutes of Health
- Citado
- 75 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Advanced MRI Techniques and Applications · Functional Brain Connectivity Studies · Advanced Neuroimaging Techniques and Applications
- Palabras clave
- caffeine, blood oxygenation level-dependent signal, adenosine receptor antagonists, theophylline, visual stimulation, auditory stimulation, functional MRI, cerebral blood flow
- MeSH
- cerebral cortex, visual cortex, auditory cortex, humans, caffeine, magnetic resonance imaging, magnetic resonance angiography, image enhancement, acoustic stimulation, single-blind method, photic stimulation, arousal, oxygen consumption, regional blood flow, reference values, coffee, image processing, computer-assisted, adult, female, male
6 autores
- Paul J. Laurienti🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Aaron S. Field🇺🇸Wake Forest University
- Jonathan H. Burdette🇺🇸Wake Forest University
- Joseph A. Maldjian🇺🇸Wake Forest University
- Yi‐Fen Yen🇺🇸Wake Forest University
- Dixon M. Moody🇺🇸Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and purpose
Recent interest has emerged in the use of pharmacologic methods to maximize blood oxygenation level-dependent (BOLD) signal intensity changes in functional MR imaging (fMRI). Adenosine antagonists, such as caffeine and theophylline, have been identified as potential agents for this purpose. The present study was designed to determine whether caffeine-induced decreases in cerebral perfusion result in enhanced BOLD responses to visual and auditory stimuli.
Methods
MR imaging was used to measure resting cerebral perfusion and stimulus-induced BOLD signal intensity changes in 19 patients. We evaluated the relationship between resting cerebral perfusion and the magnitude of BOLD signal intensity induced by visual and auditory stimulation under caffeine and placebo conditions.
Results
The data showed that changes in resting cerebral perfusion produced by caffeine are not a consistent predictor of BOLD signal intensity magnitude. Although all cerebral perfusion was reduced in all study participants in response to caffeine, only 47% of the participants experienced BOLD signal intensity increase. This finding was independent of the participants' usual caffeine consumption.
Conclusion
The data presented herein show that the relationship between resting cerebral perfusion and the magnitude of BOLD signal intensity is complex. It is not possible to consistently enhance BOLD signal intensity magnitude by decreasing resting perfusion with caffeine. Future studies aimed at evaluating the relationship between perfusion and BOLD signal intensity changes should seek a means to selectively modulate known components of the neural and vascular responses independently.
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