Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics
Gullestad L, Dolva LO, Søyland E, Manger AT, Falch D, Kjekshus J
Alcoholism, clinical and experimental research · 25 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-10-01 · Alcohol Clin Exp Res · vol. 16 · número 5 · págs. 986–990
- Editorial
- Wiley
- Citado
- 46 citas · más que el 85% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Alcoholism and Thiamine Deficiency · Alcohol Consumption and Health Effects
- Palabras clave
- oral magnesium supplementation, chronic alcoholism, hypomagnesemia, muscle strength, liver function, transaminases, gamma-glutamyl transferase, electrolyte status, serum potassium, serum magnesium, serum calcium, serum sodium, serum phosphorus, bilirubin
- MeSH
- humans, magnesium deficiency, alcoholism, magnesium, liver function tests, administration, oral, double-blind method, isometric contraction, adult, aged, middle aged
6 autores
- Lars Lysgaard Gullestad · autor de correspondencia
- L. Ø. Dolva
- Einar Søyland
- Arne Thomas Manger
- D Falch
- John Kjekshus
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium deficiency is common among chronic alcoholics, but the knowledge of oral magnesium supplementation to this group is limited. We, therefore, randomized 49 chronic alcoholics, moderate to heavy drinkers for at least 10 years to receive oral magnesium or placebo treatment for 6 weeks according to a double-blind protocol. Effects on metabolic variables and muscle strength were analyzed. Significant reduction of aspartate-aminotransferase (ASAT), alanine-aminotransferase (ALAT) and gamma-glutamyl-transpeptidase (GGT) were seen after magnesium, whereas no change was observed with placebo. Bilirubin decreased in both groups. Serum Na, Ca, and P increased significantly during magnesium therapy compared with no statistically significant change in the placebo group. Serum K and Mg increased slightly after magnesium supplementation and decreased in the placebo group, resulting in a significant difference between the two groups at the end of the study. Muscle strength increased significantly during magnesium treatment, contrasting to no change with placebo. Blood pressure, heart rate, hematological variables, serum lipids (cholesterol, HDL, TG), glucose tolerance, and creatinine were unchanged in the two groups after treatment. Alcohol consumption was similar before and during the trial and does not explain the differences between the two groups The results shows that short-term oral magnesium therapy may improve liver cell function, electrolyte status, and muscle strength in chronic alcoholics.
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