Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT
Ciubotaru I, Lee YS, Wander RC
The Journal of nutritional biochemistry · 93 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-09-01 · J Nutr Biochem · vol. 14 · número 9 · págs. 513–521
- Editorial
- Elsevier BV
- Citado
- 127 citas · más que el 96% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Antioxidant Activity and Oxidative Stress
- Palabras clave
- fish oil supplementation, dietary fish oil, C-reactive protein, interleukin-6, safflower oil, postmenopausal women, hormone replacement therapy, triglycerides, HDL cholesterol, triglyceride to HDL cholesterol ratio, low-grade inflammation, lipid profile, cardiovascular risk
- MeSH
- humans, cardiovascular diseases, dietary fats, unsaturated, safflower oil, triglycerides, fish oils, c-reactive protein, interleukin-6, placebos, estrogen replacement therapy, double-blind method, postmenopause, adult, middle aged, female, cholesterol, hdl
3 autores
- Irina Ciubotaru🇺🇸University of North Carolina at Greensboro
- Ye‐Sun Lee🇺🇸University of North Carolina at Greensboro
- Rosemary C. Wander🇺🇸 · autor de correspondenciaUniversity of North Carolina at Greensboro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. Although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear.
Objective
This study addressed the effect of supplementation with fish oil in doses achievable with diet on serum C-reactive protein (CRP), interleukin-6 (IL-6), and the lipid profile.
Methods and results
Thirty healthy subjects taking HRT were randomly divided into three groups and supplemented for five weeks with 14 g/day safflower oil (SO), 7 g/day of both safflower oil and fish oil (LFO), or 14 g/day fish oil (HFO). Measurements included serum high-sensitivity CRP, IL-6 in plasma and in cell culture supernatant collected from 24-hr lipopolysaccharide (LPS)-stimulated whole blood, and lipid profile markers. CRP and IL-6 were adjusted for body mass index (BMI). Fish oil supplementation significantly decreased CRP and IL-6 compared to SO, with a greater effect in the LFO than HFO groups. Plasma triacylglycerol (TG) and the TG/HDL-C ratio were significantly lower in the HFO compared to the SO group.
Conclusions
These results suggest that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women.
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