Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial
Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, Britton J
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 95 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-10-01 · Clin Exp Allergy · vol. 33 · número 10 · págs. 1355–1359
- Editorial
- Wiley
- Citado
- 153 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Magnesium in Health and Disease · Vitamin D Research Studies
- Palabras clave
- asthma, vitamin C supplementation, magnesium supplementation, dietary supplements, asthma control, inhaled corticosteroids, airway responsiveness, peak expiratory flow, bronchodilator use, primary care patients
- MeSH
- humans, asthma, magnesium, ascorbic acid, treatment outcome, double-blind method, treatment refusal, respiratory mechanics, adolescent, adult, middle aged, primary health care, female, male
7 autores
- Andrew Fogarty🇬🇧 · autor de correspondenciaUniversity of Nottingham; Nottingham City Hospital
- Sarah Lewis🇬🇧University of Nottingham; Nottingham City Hospital
- Sarah Scrivener🇬🇧University of Nottingham; Nottingham City Hospital
- Marilyn D. Antoniak🇬🇧University of Nottingham; Nottingham City Hospital
- Sarah J. Pacey🇬🇧University of Nottingham; Nottingham City Hospital
- Mike Pringle🇬🇧University of Nottingham; Queen's Medical Centre
- John R Britton🇬🇧University of Nottingham; Nottingham City Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies suggest that higher intakes of dietary vitamin C and magnesium may be associated with a reduced risk of asthma.
Objective
To determine whether vitamin C or magnesium supplements improve the clinical control of asthma in primary care patients.
Methods
A randomized, placebo-controlled, double-blind parallel group trial of 16 weeks supplementation with 1 g/day vitamin C, 450 mg/day magnesium chelate or matched placebo. Three hundred patients aged 18-60 years with physician-diagnosed asthma, controlled with at least one dose of an inhaled corticosteroid daily, were recruited from 24 primary care practices in Nottingham, UK. The main outcome measures were change in forced expiratory volume in 1 s, forced vital capacity, airway responsiveness to methacholine, mean morning and evening peak flow, symptom scores and bronchodilator use, both individually and as a combined summary statistic.
Results
There was no evidence of any beneficial effect of either supplement on any outcome measure of asthma control in the primary intention-to-treat analysis, or in an analysis restricted to participants who completed the study.
Conclusions
Regular dietary supplementation with vitamin C or magnesium adds no clinical benefit to current standard therapy of asthma in primary care patients.
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