Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
Johnston KL, Clifford MN, Morgan LM
The American journal of clinical nutrition · 351 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Subvenciones
- European Commission (QLK1-1999-00505)
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-10-01 · Am J Clin Nutr · vol. 78 · número 4 · págs. 728–733
- Editorial
- Elsevier BV
- Citado
- 590 citas · más que el 98% de estudios similares · 9.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Natural Antidiabetic Agents Studies · Metabolism, Diabetes, and Cancer
- Palabras clave
- coffee, chlorogenic acid, caffeine, glucose tolerance, gastrointestinal hormone secretion, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, insulin secretion, intestinal glucose absorption, dietary polyphenols, glucose uptake
- MeSH
- humans, chlorogenic acid, phenols, flavonoids, caffeine, polymers, gastrointestinal hormones, glucagon, insulin, glucose, blood glucose, peptide fragments, protein precursors, diet, area under curve, cross-over studies, postprandial period, coffee, adult, female, male, glucagon-like peptide 1, polyphenols, insulin secretion
3 autores
- Kelly L. Johnston🇬🇧University of Surrey
- Michael Newton Clifford🇬🇧University of Surrey
- Linda Morgan🇬🇧 · autor de correspondenciaUniversity of Surrey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Accumulating evidence suggests that certain dietary polyphenols have biological effects in the small intestine that alter the pattern of glucose uptake. Their effects, however, on glucose tolerance in humans are unknown.
Objective
The objective was to investigate whether chlorogenic acids in coffee modulate glucose uptake and gastrointestinal hormone and insulin secretion in humans.
Design
In a 3-way, randomized, crossover study, 9 healthy fasted volunteers consumed 25 g glucose in either 400 mL water (control) or 400 mL caffeinated or decaffeinated coffee (equivalent to 2.5 mmol chlorogenic acid/L). Blood samples were taken frequently over the following 3 h.
Results
Glucose and insulin concentrations tended to be higher in the first 30 min after caffeinated coffee consumption than after consumption of decaffeinated coffee or the control (P < 0.05 for total and incremental area under the curve for glucose and insulin). Glucose-dependent insulinotropic polypeptide secretion decreased throughout the experimental period (P < 0.005), and glucagon-like peptide 1 secretion increased 0-120 min postprandially (P < 0.01) after decaffeinated coffee consumption compared with the control. Glucose and insulin profiles were consistent with the known metabolic effects of caffeine. However, the gastrointestinal hormone profiles were consistent with delayed intestinal glucose absorption.
Conclusions
Differences in plasma glucose, insulin, and gastrointestinal hormone profiles further confirm the potent biological action of caffeine and suggest that chlorogenic acid might have an antagonistic effect on glucose transport. Therefore, a novel function of some dietary phenols in humans may be to attenuate intestinal glucose absorption rates and shift the site of glucose absorption to more distal parts of the intestine.
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