Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids
Barbosa DS, Cecchini R, El Kadri MZ, Rodríguez MA, Burini RC, Dichi I
Nutrition (Burbank, Los Angeles County, Calif.) · 126 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2003-10-01 · Nutrition · vol. 19 · número 10 · págs. 837–842
- Editorial
- Elsevier BV
- Citado
- 182 citas · más que el 95% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Inflammatory Bowel Disease · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- ulcerative colitis, fish oil, omega-3 fatty acids, oxidative stress, sulfasalazine, chemiluminescence, lipid peroxidation, malondialdehyde, superoxide dismutase, catalase, antioxidant capacity, free radicals, anti-inflammatory therapy, disease activity, erythrocyte sedimentation rate, C-reactive protein, alpha-1-acid glycoprotein
- MeSH
- colon, humans, colitis, ulcerative, reactive oxygen species, sulfasalazine, fatty acids, omega-3, fish oils, gastrointestinal agents, sigmoidoscopy, blood sedimentation, treatment outcome, drug therapy, combination, cross-over studies, lipid peroxidation, oxidative stress, adult, female, male
6 autores
- Décio Sabbatini Barbosa🇧🇷Universidade Estadual de Londrina
- Rúbens Cecchini🇧🇷Universidade Estadual de Londrina
- Mirian Zebian El Kadri🇧🇷Universidade Estadual de Londrina
- Maria Aparecida Marchesan Rodrigues🇧🇷Universidade Estadual Paulista (Unesp)
- Roberto Carlos Burini🇧🇷Universidade Estadual Paulista (Unesp)
- Isaías Dichi🇧🇷 · autor de correspondenciaUniversidade Estadual de Londrina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The potential pathogenicity of free radicals may have a pivotal role in ulcerative colitis. Fish oil omega-3 fatty acids exert anti-inflammatory effects on patients with ulcerative colitis (UC), but the precise mechanism of the action of fish oil on oxidative stress is still controversial. The aim of the present work was to verify the blood oxidative stress in patients with UC and determine whether the association of sulfasalazine to fish oil omega-3 fatty acids is more effective than isolated use of sulfasalazine to reduce the oxidative stress.
Methods
Nine patients (seven female and two male; mean age = 40 +/- 11 y) with mild or moderate active UC were studied in a randomized crossover design. In addition to their usual medication (2 g/d of sulfasalazine), they received fish oil omega-3 fatty acids (4.5 g/d) or placebo for 2-mo treatment periods that were separated by 2 mo, when they only received sulfasalazine. Nine healthy individuals served as control subjects to study the oxidative stress status. Disease activity was assessed by laboratory indicators (C-reactive protein, alpha1-acid glycoprotein, alpha1-antitrypsin, erythrocyte sedimentation rate, albumin, hemoglobin, and platelet count), sigmoidoscopy, and histology scores. Analysis of oxidative stress was assessed by plasma chemiluminescence and erythrocyte lipid peroxidation, both induced by tert butyl hydroperoxide (t-BuOOH) and by plasma malondialdehyde. Antioxidant status was assayed by total plasma antioxidant capacity (TRAP) and microsomal lipid peroxidation inhibition (LPI). Superoxide dismutase (SOD) and catalase erythrocyte enzymatic activities were also determined.
Results
No significant changes were observed in any laboratory indicator or in the sigmoidoscopy or histology scores, with the exception of erythrocyte sedimentation rate, which decreased with both treatments. Oxidative stress was demonstrated by significant decreases in TRAP and LPI levels, increased chemiluminescence induced by t-BuOOH, and higher SOD activity in patients with UC. Treatment with fish oil omega-3 fatty acids reverted the chemiluminescence induced by t-BuOOH and LPI to baseline levels but that did not occur when patients received only sulfasalazine. Levels of plasma malondialdehyde, erythrocyte lipid peroxidation, and catalase were not different from those in the control group.
Conclusions
The results indicated that plasma oxidative stress occurs in patients with UC, and there was a significant decrease when the patients used sulfasalazine plus fish oil omega-3 fatty acids. However, there was no improvement in most laboratory indicators, sigmoidoscopy, and histology scores. The results suggested that omega-3 fatty acids may act as free radical scavengers protecting the patients against the overall effect of oxidative stress.
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