Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans
Mayer K, Meyer S, Reinholz-Muhly M, Maus U, Merfels M, Lohmeyer J, Grimminger F, Seeger W
Journal of immunology (Baltimore, Md. : 1950) · 128 citas
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- Financiación
- Financiación independiente
- Gobierno
- Deutsche Forschungsgemeinschaft
- Subvenciones
- Deutsche Forschungsgemeinschaft (SFB-547)
Según 1 financiador declarado.
Publicación
- Publicado
- 2003-11-01 · J Immunol · vol. 171 · número 9 · págs. 4837–4843
- Editorial
- American Association of Immunologists
- Citado
- 191 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology · Edible Oils Quality and Analysis
- Palabras clave
- fish oil-based lipid emulsion, omega-3 fatty acids, omega-6 fatty acids, parenteral nutrition, monocytes, inflammatory cytokines, n-6/n-3 ratio, arachidonic acid, lipopolysaccharide response, TNF-α, interleukin-1, interleukin-6, interleukin-8, plasma free fatty acids, CCR2, CD11b, CD18, CD49d
- MeSH
- endothelium, vascular, monocytes, cells, cultured, humans, inflammation, fatty acids, omega-3, fat emulsions, intravenous, fatty acids, nonesterified, fatty acids, omega-6, membrane lipids, fish oils, cytokines, parenteral nutrition, infusions, intravenous, drug administration schedule, cross-over studies, sex factors, cell adhesion, leukocyte rolling, adult, female, male
8 autores
- Konstantin Mayer🇩🇪Justus-Liebig-Universität Gießen
- Sandra Meyer🇩🇪Justus-Liebig-Universität Gießen
- Marion Reinholz-Muhly🇩🇪Justus-Liebig-Universität Gießen
- Ulrich A. Maus🇩🇪Justus-Liebig-Universität Gießen
- Martina Merfels🇩🇪Justus-Liebig-Universität Gießen
- Jürgen Lohmeyer🇩🇪Justus-Liebig-Universität Gießen
- Friedrich Grimminger🇩🇪Justus-Liebig-Universität Gießen
- Werner Seeger🇩🇪Justus-Liebig-Universität Gießen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Potential impact of omega-3 fatty acids, as contained in fish oil, on immunological function has been suggested because observations of reduced inflammatory diseases in Greenland Inuit were published. A fish oil-based lipid emulsion has recently been approved for parenteral nutrition in many countries. We investigated the influence of a short infusion course of fish oil-based (omega-3) vs conventional (omega-6) lipid emulsion on monocyte function. In a randomized design, twelve healthy volunteers received omega-3 or omega-6 lipid infusion for 48 h, with cross-over repetition of the infusion course after 3 mo. Fatty acid profiles, monocyte cytokine release and adhesive monocyte-endothelium interaction were investigated. Resultant omega-6 lipid emulsion increased plasma-free fatty acids including arachidonic acid, whereas the omega-3/omega-6 fatty acid ratio in monocyte membranes remained largely unchanged. It also caused a tendency toward enhanced monocyte proinflammatory cytokine release and adhesive monocyte-endothelium interaction. In contrast, omega-3 lipid emulsion significantly increased the omega-3/omega-6 fatty acid ratio in the plasma-free fatty acid fraction and in monocyte membrane lipid pool, markedly suppressing monocyte generation of TNF-alpha, IL-1, IL-6, and IL-8 in response to endotoxin. In addition, it also significantly inhibited both monocyte-endothelium adhesion and transendothelial monocyte migration, although monocyte surface expression of relevant adhesive molecules (CD11b, CD18, CD49 days, CCR2) was unchanged. Although isocaloric, omega-3 and omega-6 lipid emulsions exert differential impact on immunological processes in humans. In addition to its nutritional value, fish oil-based omega-3 lipid emulsion significantly suppresses monocyte proinflammatory cytokine generation and features of monocyte recruitment.
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